Diffusion based MR measurements correlates with age-related changes in human intervertebral disks.
Diffusion based MR measurements correlates with age-related changes in human intervertebral disks.
复制标题
基于扩散的MR测量与人类椎间盘的年龄相关变化相关。
DOI：
10.1016/j.clinbiomech.2018.06.007
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发表时间：
2019-01
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影响因子：
--
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中科院分区：
文献类型：
--
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了解MR参数和年龄相关的人类椎间盘退化之间的关联形成了椎间盘疾病的临床诊断协议的发展中的重要一步。10具年龄37-81岁的未固定胸腰椎尸体椎间盘关节在9.4T下使用T2弛豫（CPMG）和ADC（DWI自旋回波）MR协议进行成像。对于每个MR参数，根据轴向图像计算空间图，并根据T2图分割AF和NP。线性回归测试椎间盘、髓核和纤维环中T2和ADC的均值和方差（COV）与年龄之间的相关性，以及胸椎与腰椎对这些相关性的影响。椎间盘中年龄与ADC值呈负相关（P < 0.001），与ADC值的COV（P < 0.001）和T2（P < 0.05）呈正相关。年龄与平均T2呈负相关（P < 0.01），平均ADC值（P < 0.001）且与ADC的COV呈阳性（P < 0.001）和T2与平均T2呈正相关（P < 0.05）ADC值的COV（P < 0.05）（P < 0.01）和T2与平均ADC值呈负相关（P < 0.05）与胸椎间盘相比，腰椎间盘的平均ADC值更高，（P < 0.05），平均T2较低（P < 0.001），ADC（P < 0.01）和T2（P < 0.05）的COV较高。与T2相比，MR扩散是椎间盘组织中年龄介导的变化的更敏感的测量。腰椎和胸椎的MR参数与年龄之间的显著差异表明，机械环境影响组织特异性MR参数与年龄的相关性。
Understanding the association between MR parameters and age related deterioration in human intervertebral disks forms an important step in the development of clinical diagnostic protocols for disk disease. Ten unfixed thoracic and lumbar cadaver disk joints, age 37–81 years were imaged at 9.4 T using T2 relaxation (CPMG) and ADC (DWI spin echo) MR protocols. For each MR parameter, spatial maps were computed from the axial images, with the AF and NP segmented based on the T2 maps. Linear regression tested for the correlation between mean and variance (COV) of T2 and ADC with age in the disk, nucleus and annulus, and the effect of thoracic vs. lumbar spine on these correlations. In the disk, age negatively correlated with mean ADC (P < 0.001) and positively with COV of ADC (P < 0.001) and T2 (P < 0.05). Age was negatively correlated with mean T2 (P < 0.01), mean ADC (P < 0.001) and positively with COV of ADC (P < 0.001) and T2 (P < 0.05) in the NP and positively correlated with mean T2 (P < 0.05), COV of ADC (P < 0.01) and T2 (P < 0.05) and negatively with mean ADC (P < 0.05) in the AF. Compared to thoracic disks, lumbar disks showed higher mean ADC (P < 0.05), lower mean T2 (P < 0.001) and higher COV of ADC (P < 0.01) and T2 (P < 0.05). Compared to T2, MR diffusion was a more sensitive measure of age mediated changes in disk tissues. Strong differences in the association of MR parameters with age between the lumbar and thoracic suggest that mechanical environment effects tissue specific MR parameters’ association with age.
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影响因子：
3
作者：
ADAMS, MA;HUTTON, WC
通讯作者：
HUTTON, WC
影响因子：
1.3
作者：
Kerttula, L;Kurunlahti, M;Tervonen, O
通讯作者：
Tervonen, O
影响因子：
2.8
作者：
Jomha, NM;Anoop, PC;McGann, LE
通讯作者：
McGann, LE
影响因子：
4.4
作者：
Alkalay, Ron N.;Burstein, Deborah;Westin, Carl-Fredrik;Meier, Dominick;Hackney, David B.
通讯作者：
Hackney, David B.
影响因子：
19.7
作者：
Kurunlahti, M;Kerttula, L;Tervonen, O
通讯作者：
Tervonen, O