Differences in SARS-CoV-2 Clinical Manifestations and Disease Severity in Children and Adolescents by Infecting Variant.
Differences in SARS-CoV-2 Clinical Manifestations and Disease Severity in Children and Adolescents by Infecting Variant.
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DOI：
10.3201/eid2811.220577
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发表时间：
2022-11
影响因子：
11.8
通讯作者：
中科院分区：
文献类型：
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作者：
自COVID-19大流行开始以来，已确定了不同的SARS-CoV-2变体，并与比祖先非变体菌株更高的传播性相关。在2021年1月1日至2022年1月15日期间，我们根据使用突变特异性逆转录PCR检测鉴定的感染变体，评估了美国俄亥俄州哥伦布0-21岁COVID-19门诊患者和住院患者便利样本中临床和病毒参数的差异。在研究的676名患者中，17.75%感染了非变异株，18.49%感染了α变异株，41.72%感染了Delta，16.42%感染了Omicron。SARS-COV-2/病毒合并感染的发生率为15.66%-29.41%，并且在感染变体之间具有可比性。急性Delta和Omicron感染的住院患者比非变异株感染的患者具有较低的SARS-CoV-2周期阈值和更频繁的发热和呼吸道症状。此外，SARS-COV-2/病毒合并感染和基础疾病的存在与更差的临床结局独立相关，而与感染变异无关。
Since the COVID-19 pandemic began, different SARS-CoV-2 variants have been identified and associated with higher transmissibility than the ancestral nonvariant strain. During January 1, 2021–January 15, 2022, we assessed differences in clinical and viral parameters in a convenience sample of COVID-19 outpatients and inpatients 0–21 years of age in Columbus, Ohio, USA, according to the infecting variant, identified using a mutation-specific reverse transcription PCR assay. Of the 676 patients in the study, 17.75% were infected with nonvariant strains, 18.49% with the Alpha variant, 41.72% with Delta, and 16.42% with Omicron. Rates of SARS-COV-2/viral co-infections were 15.66%–29.41% and were comparable across infecting variants. Inpatients with acute Delta and Omicron infections had lower SARS-CoV-2 cycle threshold values and more frequent fever and respiratory symptoms than those with nonvariant strain infections. In addition, SARS-COV-2/viral co-infections and the presence of underlying conditions were independently associated with worse clinical outcomes, irrespective of the infecting variant.
影响因子：
3.9
作者：
Smith DR;Singh C;Green J;Lueder MR;Arnold CE;Voegtly LJ;Long KA;Rice GK;Luquette AE;Miner HL;Glang L;Bennett AJ;Miller RH;Malagon F;Cer RZ;Bishop-Lilly KA
通讯作者：
Bishop-Lilly KA
DOI：
10.1016/j.revmed.2012.04.014
发表时间：
2012-11
期刊：
La Revue de medecine interne
影响因子：
--
作者：
Régent A;Kluger N;Bérezné A;Lassoued K;Mouthon L
通讯作者：
Mouthon L