Reactive oxygen species prevent imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function.
Reactive oxygen species prevent imiquimod-induced psoriatic dermatitis through enhancing regulatory T cell function.
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DOI：
10.1371/journal.pone.0091146
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Seoh JY
中科院分区：
文献类型：
--
作者：
Kim HR;Lee A;Choi EJ;Hong MP;Kie JH;Lim W;Lee HK;Moon BI;Seoh JY
牛皮癣是免疫失调引起的慢性炎症性皮肤疾病。许多最近的研究表明，ROS在免疫介导的疾病中的保护作用尤其是牛皮癣。通过高压氧疗法（HBOT）成功处理，据报道，TREG功能与ROS水平紧密相关为了阐明ROS水平与Treg功能之间的关系及其在牛皮癣的发病机理中的作用，我们研究了咪喹莫夫诱导的牛皮癣通过使用基因敲除小鼠，例如谷胱甘肽过氧化物酶-1 - / - 和中性粒细胞胞质因子1 - / - 小鼠，以及使用HBOT或化学物质或化学药品，与Treg功能在ROS的升高和降低水平中与Treg功能相关，以及使用HBOT或化学物质或化学药品，例如2,3-二甲氧基-1,4-萘喹酮和N-乙酰半胱氨酸。 ROS的水平。此外，在ROS的水平升高中，咪喹莫夫诱导的PD降低了，而ROS水平的汇总可能会连接ROS水平和TREG功能。在PD病变中，ROS诱导的2,3-二加氧酶（IDO）。通过增强IDO表达和Treg功能来预防牛皮癣。
Psoriasis is a chronic inflammatory skin disease resulting from immune dysregulation. Regulatory T cells (Tregs) are important in the prevention of psoriasis. Traditionally, reactive oxygen species (ROS) are known to be implicated in the progression of inflammatory diseases, including psoriasis, but many recent studies suggested the protective role of ROS in immune-mediated diseases. In particular, severe cases of psoriasis vulgaris have been reported to be successfully treated by hyperbaric oxygen therapy (HBOT), which raises tissue level of ROS. Also it was reported that Treg function was closely associated with ROS level. However, it has been only investigated in lowered levels of ROS so far. Thus, in this study, to clarify the relationship between ROS level and Treg function, as well as their role in the pathogenesis of psoriasis, we investigated imiquimod-induced psoriatic dermatitis (PD) in association with Treg function both in elevated and lowered levels of ROS by using knockout mice, such as glutathione peroxidase-1−/− and neutrophil cytosolic factor-1−/− mice, as well as by using HBOT or chemicals, such as 2,3-dimethoxy-1,4-naphthoquinone and N-acetylcysteine. The results consistently showed Tregs were hyperfunctional in elevated levels of ROS, whereas hypofunctional in lowered levels of ROS. In addition, imiquimod-induced PD was attenuated in elevated levels of ROS, whereas aggravated in lowered levels of ROS. For the molecular mechanism that may link ROS level and Treg function, we investigated the expression of an immunoregulatory enzyme, indoleamine 2,3-dioxygenase (IDO) which is induced by ROS, in PD lesions. Taken together, it was implied that appropriately elevated levels of ROS might prevent psoriasis through enhancing IDO expression and Treg function.
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