Depressive symptoms and risk of type 2 diabetes in a national sample of middle-aged and older adults: the English longitudinal study of aging.
Depressive symptoms and risk of type 2 diabetes in a national sample of middle-aged and older adults: the English longitudinal study of aging.
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DOI：
10.2337/dc09-1663
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发表时间：
2010-04
期刊：
影响因子：
16.2
通讯作者：
Hardy R
中科院分区：
文献类型：
--
作者：
Demakakos P;Pierce MB;Hardy R
在全国50岁以上人群样本中研究基线抑郁症状升高与2型糖尿病发病之间的关系。样本包括6,111名在2002-2003年基线时没有自我报告的医生诊断的糖尿病的人。流行病学抑郁中心（CES-D）的八项量表是抑郁症状的测量。考克斯比例风险回归模型用于评估基线升高（≥4）的抑郁症状是否与45.8个月随访期间2型糖尿病的高风险相关。在调整了年龄、性别、婚姻状况、教育程度、家庭总净财富、心血管和精神疾病以及其他非心血管合并症、BMI和健康行为的模型中，与无症状受试者相比，CES-D症状升高的受试者的糖尿病风险比（HR）为1.62（95%CI 1.15-2.29）。对子样本（n = 5，090）进行的补充分析显示，对该模型进行抗抑郁药使用的额外调整并不能解释相关性（HR 1.58，95% CI 1.09-2.29）。在考虑了社会人口学、生活方式和临床因素后，在全国范围内年龄≥50岁的人群中，抑郁症状升高与2型糖尿病的发生风险升高相关。
To examine the association between baseline elevated depressive symptoms and incident type 2 diabetes in a national sample of people aged ≥50 years. The sample consisted of 6,111 individuals free from self-reported doctor-diagnosed diabetes at baseline in 2002–2003. The eight-item Center for Epidemiological Studies–Depression (CES-D) scale was the measurement of depressive symptoms. Cox proportional hazards regression models were used to assess whether baseline elevated (≥4) depressive symptoms were associated with a higher risk of type 2 diabetes over 45.8 months of follow-up. The hazard ratio (HR) for diabetes was 1.62 (95% CI 1.15–2.29) in a model adjusted for age, sex, marital status, education, total net household wealth, cardiovascular and psychiatric and other noncardiovascular comorbidities, BMI, and health behaviors for participants with elevated CES-D symptoms compared with those without. Complementary analysis performed for a subsample (n = 5,090) showed that additional adjustment of this model for use of antidepressants did not explain the association (HR 1.58, 95% CI 1.09–2.29). Elevated depressive symptoms were associated with a higher risk of developing type 2 diabetes after accounting for sociodemographic, lifestyle, and clinical factors in a national sample of people aged ≥50 years.
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影响因子：
4.7
作者：
Engum, Anne
通讯作者：
Engum, Anne
影响因子：
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作者：
Saydah, SH;Brancati, FL;Harris, MI
通讯作者：
Harris, MI
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通讯作者：
Pouwer, F
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作者：
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通讯作者：
Lyketsos, Constantine
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作者：
RADLOFF L S
通讯作者：
RADLOFF L S