Genetic variants of CHRNA5-A3 and CHRNB3-A6 predict survival of patients with advanced non-small cell lung cancer.
Genetic variants of CHRNA5-A3 and CHRNB3-A6 predict survival of patients with advanced non-small cell lung cancer.
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CHRNA5-A3 和 CHRNB3-A6 的遗传变异可预测晚期非小细胞肺癌患者的生存
DOI：
10.18632/oncotarget.8510
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发表时间：
2016-05-03
期刊：
影响因子：
--
通讯作者：
Song Y
中科院分区：
文献类型：
--
作者：
Wang Y;Peng X;Zhu L;Hu L;Song Y
烟碱型乙酰胆碱受体(NAChRs)在肺癌的发生发展中起关键作用，而编码nAChR亚单位的两个基因簇CHRNA5-A3和CHRNB3-A6的多态与肺癌的易感性有关。在这项研究中，我们调查了这两个基因簇的变异是否与晚期非小细胞肺癌(NSCLC)的预后有关。本研究共纳入165例IIIB-IV期非小细胞肺癌患者。用TaqMan方法对CHRNA5-A3的rs667282和rs3743073以及CHRNB3-A6的rs13280604进行了基因分型。总生存期(OS)采用对数等级检验和COX模型。结果显示，携带TT或TC基因的CHRNA5-A3rs667282患者的OS明显短于携带CC基因的患者(对数列，P=0.043)。此外，多变量COX回归分析显示rs667282TT/TC基因型与总体死亡风险的增加显著相关(调整后的危险比为1.7；95%可信区间为1.1-2.7)。然而，在其他两个多态中没有观察到类似的结果。此外，这些变异与晚期非小细胞肺癌的临床病理特征之间没有明显的关联。我们的研究提示，CHRNA5-A3的rs667282基因可能改变晚期NSCLC患者的预后。
Nicotinic acetylcholine receptors (nAChRs) play a key role in carcinogenesis and progression of lung cancer; and polymorphisms in CHRNA5-A3 and CHRNB3-A6, two gene clusters encoding nAChR subunits, have been associated with lung cancer risk. In this study, we investigated whether variants in the two gene clusters were associated with prognosis of advanced non-small cell lung cancer (NSCLC). A total of 165 stage IIIB–IV NSCLC patients were enrolled in this study. Three polymorphisms (rs667282 and rs3743073 in CHRNA5-A3 and rs13280604 in CHRNB3-A6) were genotyped using the TaqMan method. Overall survival (OS) was estimated using the log-rank test and the Cox models. Our results showed that patients with CHRNA5-A3 rs667282 TT or TC genotypes had a significantly shorter OS than those carrying the CC genotype (Log-rank, P = 0.043). Furthermore, multivariate Cox regression analysis showed that rs667282 TT/TC genotypes are significantly associated with increased risk of overall deaths (adjusted hazard ratio, 1.7; 95% CI, 1.1–2.7). However, the similar results were not observed for other two polymorphisms. Furthermore, no evident association was found between these variants and clinicopathologic features of advanced NSCLC. Our present study suggested that rs667282 in CHRNA5-A3 may modify the prognosis of patients with advanced NSCLC.
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DOI：
10.1093/jnci/88.17.1210
发表时间：
1996-09-04
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Dillman, RO;Herndon, J;Green, MR
通讯作者：
Green, MR
15q25 染色体遗传变异与中国人群肺癌风险相关
影响因子：
11.2
作者：
Wu, Chen;Hu, Zhibin;Shen, Hongbing
通讯作者：
Shen, Hongbing
影响因子：
45.3
作者：
FINKELSTEIN, DM;ETTINGER, DS;RUCKDESCHEL, JC
通讯作者：
RUCKDESCHEL, JC
DOI：
10.1111/j.1360-0443.2012.03922.x
发表时间：
2012-11
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Rice JP;Hartz SM;Agrawal A;Almasy L;Bennett S;Breslau N;Bucholz KK;Doheny KF;Edenberg HJ;Goate AM;Hesselbrock V;Howells WB;Johnson EO;Kramer J;Krueger RF;Kuperman S;Laurie C;Manolio TA;Neuman RJ;Nurnberger JI;Porjesz B;Pugh E;Ramos EM;Saccone N;Saccone S;Schuckit M;Bierut LJ;GENEVA Consortium
通讯作者：
GENEVA Consortium
影响因子：
254.7
作者：
Torre, Lindsey A.;Bray, Freddie;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin