CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.
CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.
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DOI：
10.1111/j.1360-0443.2012.03922.x
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
GENEVA Consortium
中科院分区：
文献类型：
--
作者：
Rice JP;Hartz SM;Agrawal A;Almasy L;Bennett S;Breslau N;Bucholz KK;Doheny KF;Edenberg HJ;Goate AM;Hesselbrock V;Howells WB;Johnson EO;Kramer J;Krueger RF;Kuperman S;Laurie C;Manolio TA;Neuman RJ;Nurnberger JI;Porjesz B;Pugh E;Ramos EM;Saccone N;Saccone S;Schuckit M;Bierut LJ;GENEVA Consortium
尼古丁依赖是一种与严重的医学发病率和死亡率相关的高度遗传性疾病。最近的荟萃分析发现了新的基因位点与每天吸烟（CPD）有关，CPD是尼古丁依赖的一个代表。本文的目的是评估表型定义（即CPD与Fagerström香烟依赖测试（FTCD）评分作为尼古丁依赖的测量）在尼古丁依赖全基因组关联研究中的重要性。全基因组关联研究社区样本从成瘾研究：遗传与环境（SAGE）中选择了至少抽过一支烟的3365名受试者。在参与者中，2267名是欧洲裔美国人，999名是非裔美国人。尼古丁依赖由FTCD评分≥4，CPD定义。与尼古丁依赖相关性最强的遗传位点为CHRNB3区域8号染色体上的rs1451240 （OR=0.65, p=2.4×10−8）。这种关联在先前发表的数据集的荟萃分析中得到进一步加强（合并p=6.7 ×10−16，总n=4,200）。当CPD被用作替代表型时，这种关联不再达到全基因组显著性（β= - 0.08, p=0.0007）。每日卷烟消费和Fagerstrom香烟依赖测试（FTCD）显示不同的基因位点多态性的关联。
Nicotine dependence is a highly heritable disorder associated with severe medical morbidity and mortality. Recent meta-analyses have found novel genetic loci associated with cigarettes per day (CPD), a proxy for nicotine dependence. The aim of this paper is to evaluate the importance of phenotype definition (i.e. CPD versus Fagerström Test for Cigarette Dependence (FTCD) score as a measure of nicotine dependence) on genome-wide association studies of nicotine dependence. Genome-wide association study Community sample A total of 3,365 subjects who had smoked at least one cigarette were selected from the Study of Addiction: Genetics and Environment (SAGE). Of the participants, 2,267 were European Americans,999 were African Americans. Nicotine dependence defined by FTCD score ≥4, CPD The genetic locus most strongly associated with nicotine dependence was rs1451240 on chromosome 8 in the region of CHRNB3 (OR=0.65, p=2.4×10−8). This association was further strengthened in a meta-analysis with a previously published dataset (combined p=6.7 ×10−16, total n=4,200).When CPD was used as an alternate phenotype, the association no longer reached genome-wide significance (β=−0.08, p=0.0007). Daily cigarette consumption and the Fagerstrom Test for Cigarette Dependence (FTCD) show different associations with polymorphisms in genetic loci.
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DOI：
10.1002/ajmg.b.31027
发表时间：
2010-03-05
影响因子：
2.8
作者：
Ehringer, Marissa A.;McQueen, Matthew B.;Hoft, Nicole R.;Saccone, Nancy L.;Stitzel, Jerry A.;Wang, Jen C.;Bierut, Laura J.
通讯作者：
Bierut, Laura J.
DOI：
10.1111/j.1601-183x.2009.00495.x
发表时间：
2009-08
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Hoft NR;Corley RP;McQueen MB;Huizinga D;Menard S;Ehringer MA
通讯作者：
Ehringer MA
影响因子：
11.2
作者：
Saccone NL;Wang JC;Breslau N;Johnson EO;Hatsukami D;Saccone SF;Grucza RA;Sun L;Duan W;Budde J;Culverhouse RC;Fox L;Hinrichs AL;Steinbach JH;Wu M;Rice JP;Goate AM;Bierut LJ
通讯作者：
Bierut LJ
DOI：
10.1038/npp.2008.122
发表时间：
2009-02
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
30.8
作者：
Sanna, Serena;Jackson, Anne U.;Mohlke, Karen L.
通讯作者：
Mohlke, Karen L.