Controlling inflammation: a fat chance?

Controlling inflammation: a fat chance?
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控制炎症:胖子的机会?

DOI:
10.1084/jem.20050222
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发表时间:
2005-03-07
期刊:
The Journal of experimental medicine
影响因子:
--
通讯作者:
Perretti M
Perretti M
中科院分区:
其他
文献类型:
--
作者:
Flower RJ;Perretti M

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炎症反应保护身体免受感染和伤害,但本身可能会放松管制,给宿主带来有害后果。现在清楚的是,在防御反应中激活的几个内源性生化途径可以对抗炎症。新的实验证据为这组内源性抑制物添加了解决素E1,并为在饮食中补充鱼油的有益效果提供了进一步的理论基础。它还突显了阿司匹林药理上的一个意想不到的转折。
The inflammatory response protects the body against infection and injury but can itself become deregulated with deleterious consequences to the host. It is now clear that several endogenous biochemical pathways activated during defense reactions can counterregulate inflammation. New experimental evidence adds resolvin E1 to this group of endogenous inhibitors and provides further rationale for the beneficial effects of dietary supplementation with fish oils. It also highlights an unexpected twist in the pharmacology of aspirin.
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