Serotonergic function, two-mode models of self-regulation, and vulnerability to depression: what depression has in common with impulsive aggression.
Serotonergic function, two-mode models of self-regulation, and vulnerability to depression: what depression has in common with impulsive aggression.
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DOI：
10.1037/a0013740
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发表时间：
2008-11
影响因子：
22.4
通讯作者：
Joormann, Jutta
中科院分区：
文献类型：
--
作者：
Carver, Charles S.;Johnson, Sheri L.;Joormann, Jutta
来自不同文献的证据支持这样的观点，即存在两种自我调节模式，一种是对当下的联想线索快速反应的低阶系统，一种是反应更有反思性和计划性的高阶系统;低能量功能与低阶系统的相对优势有关;低阶系统的优势如何表现取决于附加变量;因此，较低的肾上腺素能功能可以促进行为模式的差异，如冲动性攻击和昏睡性抑郁。回顾的文献包括双模式模型的工作;支持双模式观点的生物可接受性的脑功能研究和与之相关的功能中的多巴胺能通路的参与;以及与冲动，攻击（包括极端暴力），人格方面和抑郁症脆弱性有关的低多巴胺能功能的研究。抑郁症和其他现象之间的实质性差异进行了解释，提出抑郁症反映了低神经元功能和低奖励敏感性。文章结束时简要考虑的想法，低的负能功能涉及到更多样化的现象，其性质部分取决于其他系统的敏感性。
Evidence from diverse literatures supports the viewpoint that two modes of self-regulation exist, a lower-order system that responds quickly to associative cues of the moment and a higher-order system that responds more reflectively and planfully; that low serotonergic function is linked to relative dominance of the lower-order system; that how dominance of the lower-order system is manifested depends on additional variables; and that low serotonergic function therefore can promote behavioral patterns as divergent as impulsive aggression and lethargic depression. Literatures reviewed include work on two-mode models; studies of brain function supporting the biological plausibility of the two-mode view and the involvement of serotonergic pathways in functions pertaining to it; and studies relating low serotonergic function to impulsiveness, aggression (including extreme violence), aspects of personality, and depression vulnerability. Substantial differences between depression and other phenomena reviewed are interpreted by proposing that depression reflects both low serotonergic function and low reward sensitivity. The article closes with brief consideration of the idea that low serotonergic function relates to even more diverse phenomena, whose natures depend in part on sensitivities of other systems.
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DOI：
10.1196/annals.1301.025
发表时间：
2003-01-01
期刊：
ROOTS OF MENTAL ILLNESS IN CHILDREN
影响因子：
--
作者：
Beitchman, JH;Davidge, KM;Douglas, L
通讯作者：
Douglas, L
影响因子：
5.3
作者：
Beauregard, M;Lévesque, J;Bourgouin, P
通讯作者：
Bourgouin, P
影响因子：
1.7
作者：
Abercrombie, HC;Schaefer, SM;Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
11.3
作者：
AGREN, H
通讯作者：
AGREN, H
影响因子：
8.2
作者：
Beer, JS;Knight, RT;D'Esposito, M
通讯作者：
D'Esposito, M