Interface between normal and transformed epithelial cells: A road to a novel type of cancer prevention and treatment
Interface between normal and transformed epithelial cells: A road to a novel type of cancer prevention and treatment
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正常和转化上皮细胞之间的界面：新型癌症预防和治疗之路
DOI：
10.1111/j.1349-7006.2011.02011.x
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发表时间：
2011
期刊：
影响因子：
5.7
通讯作者：
Yasuyuki Fujita
中科院分区：
文献类型：
--
作者：
Yasuyuki Fujita
细胞转化由癌蛋白的激活和/或肿瘤抑制蛋白的失活引起。在癌变的初始阶段，转化发生在上皮单层内的单个细胞中。然而，目前尚不清楚一旦发生初始转化，正常细胞和转化细胞之间的界面会发生什么。最近的报道表明，使用精心设计的细胞培养系统，正常和转化的上皮细胞之间的相互作用可以诱导各种现象。例如，当Ras或Src转化的细胞被正常上皮细胞包围时，多种信号传导途径被激活，转化的细胞从上皮顶端挤出。此外，正常和某些类型的转化细胞相互竞争细胞存活，转化细胞发生凋亡。重要的是，当转化细胞单独存在时，既不会发生细胞凋亡也不会从上皮细胞中消除，这表明周围正常细胞的存在影响转化细胞的信号传导途径和命运。在斑马鱼和小鼠体内模型系统中也观察到类似的现象。在这篇综述中，我将介绍这一新兴的研究领域，并讨论这些研究如何可能导致建立新类型的癌症预防和治疗。（Cancer Sci 2011; 102：1749-1755）
Cell transformation arises from activation of oncoproteins and/or inactivation of tumor suppressor proteins. During the initial stage of carcinogenesis, transformation occurs in a single cell within an epithelial monolayer. However, it is not known what happens at the interface between normal and transformed cells once the initial transformation has occurred. Using elaborate cell culture systems, recent reports have shown that interactions between normal and transformed epithelial cells can induce various phenomena. For example, when Ras‐ or Src‐transformed cells are surrounded by normal epithelial cells, multiple signaling pathways are activated and the transformed cells are apically extruded from the epithelium. In addition, normal and certain types of transformed cells compete with each other for cell survival, and the transformed cells undergo apoptosis. Importantly, when transformed cells alone are present, neither apoptosis nor elimination from epithelia occurs, indicating that the presence of surrounding normal cells influences the signaling pathways and fate of transformed cells. Comparable phenomena are also observed in zebrafish and mice in vivo model systems. In this review, I will introduce this newly emerging research field and discuss how these studies can potentially lead to establishment of novel types of cancer prevention and treatment. (Cancer Sci 2011; 102: 1749–1755)
影响因子：
11.8
作者：
Egeblad, Mikala;Nakasone, Elizabeth S.;Werb, Zena
通讯作者：
Werb, Zena
影响因子：
29.4
作者：
Oertel, M;Menthena, A;Shafritz, DA
通讯作者：
Shafritz, DA
影响因子：
2.7
作者：
Foty, RA;Steinberg, MS
通讯作者：
Steinberg, MS