Development of leptin resistance in sucrose drinking rats is associated with consuming carbohydrate-containing solutions and not calorie-free sweet solution.
Development of leptin resistance in sucrose drinking rats is associated with consuming carbohydrate-containing solutions and not calorie-free sweet solution.
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DOI：
10.1016/j.appet.2018.10.015
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发表时间：
2019-01-01
期刊：
影响因子：
5.4
通讯作者：
Harris RBS
中科院分区：
文献类型：
--
作者：
Harris RBS
给予30%蔗糖溶液加饲料或无蔗糖饮食的大鼠在4周内出现瘦素抵抗。这个实验测试了瘦素抵抗是否与甜味的奖励或简单碳水化合物摄入的吸收前或吸收后的影响有关。雄性Sprague Dawley大鼠分别饲喂无蔗糖日粮（NS）、含67%热量的蔗糖日粮（HS）或NS日粮加30%蔗糖（LS）、0.03%糖精（Sacc）或20% SolCarb®溶液38天。SolCarb®是一种麦芽糊精粉末。Sacc大鼠最初比LS大鼠喝得多，但20天后摄入量相同。从第15天到实验结束，SolCarb®和LS大鼠饮用相同数量的卡路里。SolCarb®和LS大鼠的干粮摄取量低于其他各组，但总能量摄取量高于NS、HS和Sacc组，且碳水化合物占总能量摄取量的80%以上。在第27天和第32天测试瘦素反应性，每只大鼠作为自己的对照。腹腔注射2 mg/Kg瘦素可抑制NS、HS和Sacc大鼠的食物摄取量，但对LS或SolCarb®大鼠的能量摄取量以及Sacc、蔗糖或SolCarb®溶液的摄取量无影响。实验结束时，所有的大鼠都对胰岛素敏感，具有相同的身体成分和血清瘦素浓度。这些数据表明，摄入含有卡路里的碳水化合物溶液而不是甜味会导致瘦素抵抗的发展，并表明瘦素抑制饥饿的阈值低于抑制奖励的阈值。
Rats offered 30% sucrose solution plus chow or a sucrose-free diet develop leptin resistance within 4 weeks. This experiment tested whether leptin resistance was associated with the reward of sweet taste or the pre- or post-absorptive effects of consumption of simple carbohydrate. Male Sprague Dawley rats were offered a sucrose-free diet (NS), a diet containing 67% calories as sucrose (HS) or NS diet plus 30% sucrose (LS), 0.03% saccharin (Sacc) or 20% SolCarb® solution for 38 days. SolCarb® is a maltodextrin powder. Sacc rats initially drank more than LS rats, but intakes were the same after Day 20. SolCarb® and LS rats drank the same number of calories from Day 15 to the end of the experiment. SolCarb® and LS rats ate less dry food than other groups, but total energy intake was greater than that of NS, HS and Sacc groups and over 80% of their energy intake was from carbohydrate. Leptin responsiveness was tested on Days 27 and 32 with each rat acting as its own control. An i.p. injection of 2 mg/Kg leptin inhibited food intake of NS, HS and Sacc rats, but had no effect on energy intake of LS or SolCarb® rats or on consumption of Sacc, sucrose or SolCarb® solution. At the end of the experiment all of the rats were insulin sensitive, had the same body composition and serum leptin concentrations. These data indicate that consumption of a calorie containing carbohydrate solution and not sweet taste drives the development of leptin resistance and suggest that there is lower threshold for inhibition of hunger than for inhibition of reward by leptin.
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影响因子：
29
作者：
Fernandes, Maria Fernanda A.;Matthys, Dominique;Fulton, Stephanie
通讯作者：
Fulton, Stephanie
DOI：
10.1152/ajpregu.00384.2017
发表时间：
2018-04-01
影响因子：
2.8
作者：
Harris, Ruth B. S.
通讯作者：
Harris, Ruth B. S.
影响因子：
5.3
作者：
Treesukosol, Yada;Smith, Kimberly R.;Spector, Alan C.
通讯作者：
Spector, Alan C.
影响因子：
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作者：
Lindqvist, Andreas;Baelemans, Annernie;Erlanson-Albertsson, Charlotte
通讯作者：
Erlanson-Albertsson, Charlotte
影响因子：
2.9
作者：
Myers, Kevin P.;Taddeo, Marisa S.;Richards, Emily K.
通讯作者：
Richards, Emily K.