Meta-analysis reveals that genes regulated by the Y chromosome in Drosophila melanogaster are preferentially localized to repressive chromatin.
Meta-analysis reveals that genes regulated by the Y chromosome in Drosophila melanogaster are preferentially localized to repressive chromatin.
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DOI：
10.1093/gbe/evt005
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发表时间：
2013
影响因子：
3.3
通讯作者：
Hartl DL
中科院分区：
文献类型：
--
作者：
Sackton TB;Hartl DL
果蝇Y染色体是一条退化的异染色质染色体，几乎没有功能基因。尽管如此，D.黑腹果蝇对X连锁和常染色体基因的调节具有实质性的反式作用。然而，目前尚不清楚这些基因是否只是代表基因组的随机子集，或者特定的功能特性是否与Y连锁变异的调控易感性相关。在这里，我们提出了一个荟萃分析四个先前发表的微阵列研究Y连锁调控变异（YRV）在D。黑腹菌我们表明，YRV基因是远远从基因组的随机子集：他们更有可能是在抑制染色质的背景下，表达组织特异性，并在不同物种内和之间的表达比非YRV基因。此外，YRV基因比非YRV基因更可能与核纤层相关联，并且通常更可能在核中彼此靠近（尽管不是沿沿着）。综上所述，这些结果表明，Y染色体上的变异在改变基因组在染色质区室中的分布方式中起作用，无论是通过DNA结合蛋白的分布变化，还是通过细胞核中基因组空间排列的变化。
The Drosophila Y chromosome is a degenerated, heterochromatic chromosome with few functional genes. Despite this, natural variation on the Y chromosome in D. melanogaster has substantial trans-acting effects on the regulation of X-linked and autosomal genes. It is not clear, however, whether these genes simply represent a random subset of the genome or whether specific functional properties are associated with susceptibility to regulation by Y-linked variation. Here, we present a meta-analysis of four previously published microarray studies of Y-linked regulatory variation (YRV) in D. melanogaster. We show that YRV genes are far from a random subset of the genome: They are more likely to be in repressive chromatin contexts, be expressed tissue specifically, and vary in expression within and between species than non-YRV genes. Furthermore, YRV genes are more likely to be associated with the nuclear lamina than non-YRV genes and are generally more likely to be close to each other in the nucleus (although not along chromosomes). Taken together, these results suggest that variation on the Y chromosome plays a role in modifying how the genome is distributed across chromatin compartments, either via changes in the distribution of DNA-binding proteins or via changes in the spatial arrangement of the genome in the nucleus.
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影响因子：
3.3
作者：
Jiang, Pan-Pan;Hartl, Daniel L.;Lemos, Bernardo
通讯作者：
Lemos, Bernardo
影响因子：
4.1
作者：
Kopp, A;Frank, AK;Barmina, O
通讯作者：
Barmina, O
影响因子：
4.1
作者：
Kopp, A;Frank, A;Fu, J
通讯作者：
Fu, J
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
DOI：
10.1073/pnas.231484998
发表时间：
2001-11-06
影响因子：
11.1
作者：
Carvalho, AB;Dobo, BA;Clark, AG
通讯作者：
Clark, AG