Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution.
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution.
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DOI：
10.1038/ng.2568
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发表时间：
2013-04
期刊：
影响因子：
30.8
通讯作者：
Li, Weiming
中科院分区：
文献类型：
--
作者：
Smith, Jeramiah J.;Kuraku, Shigehiro;Holt, Carson;Sauka-Spengler, Tatjana;Jiang, Ning;Campbell, Michael S.;Yandell, Mark D.;Manousaki, Tereza;Meyer, Axel;Bloom, Ona E.;Morgan, Jennifer R.;Buxbaum, Joseph D.;Sachidanandam, Ravi;Sims, Carrie;Garruss, Alexander S.;Cook, Malcolm;Krumlauf, Robb;Wiedemann, Leanne M.;Sower, Stacia A.;Decatur, Wayne A.;Hall, Jeffrey A.;Amemiya, Chris T.;Saha, Nil R.;Buckley, Katherine M.;Rast, Jonathan P.;Das, Sabyasachi;Hirano, Masayuki;McCurley, Nathanael;Guo, Peng;Rohner, Nicolas;Tabin, Clifford J.;Piccinelli, Paul;Elgar, Greg;Ruffier, Magali;Aken, Bronwen L.;Searle, Stephen M. J.;Muffato, Matthieu;Pignatelli, Miguel;Herrero, Javier;Jones, Matthew;Brown, C. Titus;Chung-Davidson, Yu-Wen;Nanlohy, Kaben G.;Libants, Scot V.;Yeh, Chu-Yin;McCauley, David W.;Langeland, James A.;Pancer, Zeev;Fritzsch, Bernd;de Jong, Pieter J.;Zhu, Baoli;Fulton, Lucinda L.;Theising, Brenda;Flicek, Paul;Bronner, Marianne E.;Warren, Wesley C.;Clifton, Sandra W.;Wilson, Richard K.;Li, Weiming
七鳃鳗是一个古老的脊椎动物谱系的代表，从我们自己的分歧约5亿年前。凭借这种深深共享的祖先，海七鳃鳗（P. marinus）基因组是唯一准备提供深入了解脊椎动物基因组的祖先和脊椎动物生物学的基本原则。在这里，我们提出了第一个七鳃鳗全基因组序列和组装。我们注意到由于其高含量的重复元件和GC碱基以及缺乏来自密切相关物种的大规模序列信息而面临的挑战。分析的大会表明，两个全基因组复制可能发生在祖先七鳃鳗和gnathostome血统的分歧。此外，这些结果有助于确定脊椎动物谱系中的关键进化事件，包括髓鞘相关蛋白的起源和附件的发育。七鳃鳗基因组为重建脊椎动物起源和塑造现存生物基因组的进化事件提供了重要资源。
Lampreys are representatives of an ancient vertebrate lineage that diverged from our own ~500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) genome is uniquely poised to provide insight into the ancestry of vertebrate genomes and the underlying principles of vertebrate biology. Here, we present the first lamprey whole-genome sequence and assembly. We note challenges faced owing to its high content of repetitive elements and GC bases, as well as the absence of broad-scale sequence information from closely related species. Analyses of the assembly indicate that two whole-genome duplications likely occurred before the divergence of ancestral lamprey and gnathostome lineages. Moreover, the results help define key evolutionary events within vertebrate lineages, including the origin of myelin-associated proteins and the development of appendages. The lamprey genome provides an important resource for reconstructing vertebrate origins and the evolutionary events that have shaped the genomes of extant organisms.
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