Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand's university-based referral hospital.
Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand's university-based referral hospital.
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DOI：
10.1186/s12879-021-06081-z
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发表时间：
2021-04-26
影响因子：
3.7
通讯作者：
Kantakamalakul W
中科院分区：
文献类型：
--
作者：
Sirijatuphat R;Suputtamongkol Y;Angkasekwinai N;Horthongkham N;Chayakulkeeree M;Rattanaumpawan P;Koomanachai P;Assanasen S;Rongrungruang Y;Chierakul N;Ratanarat R;Jitmuang A;Wangchinda W;Kantakamalakul W
泰国新冠肺炎患者的流行病学和预后很少见。这项回顾性队列研究包括2020年2月至2020年4月期间在西里拉杰医院被诊断为新冠肺炎的成年住院患者。在暴发期间接受RT-PCRSARS-CoV-2检测的1 409例患者中，新冠肺炎的感染率为7.5%(107例新冠肺炎患者)。94.4%的新冠肺炎患者出现症状。在104例接受抗病毒药物治疗的患者中，78例(75%)接受了2种药物方案(洛比那韦/利托那韦或达鲁那韦/利托那韦+氯喹或羟基氯喹)，26例(25%)在2种药物方案的基础上加用了法韦拉韦。有18名患者(16.8%)观察到疾病进展。所有新冠肺炎患者均安全出院。在接受逆转录聚合酶链式反应检测的患者中，新冠肺炎的患病率为7.5%，在那些具有新冠肺炎获取风险因素的患者中，患病率为10%。新冠肺炎患者的联合抗病毒治疗耐受性良好，并产生了良好的结果。
The epidemiology and outcomes of COVID-19 patients in Thailand are scarce. This retrospective cohort study included adult hospitalized patients who were diagnosed with COVID-19 at Siriraj Hospital during February 2020 to April 2020. The prevalence of COVID-19 was 7.5% (107 COVID-19 patients) among 1409 patients who underwent RT-PCR for SARS-CoV-2 detection at our hospital during the outbreak period. Patients with COVID-19 presented with symptoms in 94.4%. Among the 104 patients who were treated with antiviral medications, 78 (75%) received 2-drug regimen (lopinavir/ritonavir or darunavir/ritonavir plus chloroquine or hydroxychloroquine), and 26 (25%) received a 3-drug regimen with favipiravir added to the 2-drug regimen. Disease progression was observed in 18 patients (16.8%). All patients with COVID-19 were discharged alive. The prevalence of COVID-19 was 7.5% among patients who underwent RT-PCR testing, and 10% among those having risk factors for COVID-19 acquisition. Combination antiviral therapies for COVID-19 patients were well-tolerated and produced a favorable outcome.
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影响因子：
3.3
作者：
Sivakorn, Chaisith;Luvira, Viravarn;Iamsirithaworn, Sopon
通讯作者：
Iamsirithaworn, Sopon
影响因子：
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通讯作者：
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影响因子：
11.8
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