Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population.
Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population.
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DOI：
10.1186/1471-2377-11-89
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发表时间：
2011-07-25
期刊：
影响因子：
2.6
通讯作者：
Fukuoka Kinki Parkinson's Disease Study Group
中科院分区：
文献类型：
--
作者：
Kiyohara C;Miyake Y;Koyanagi M;Fujimoto T;Shirasawa S;Tanaka K;Fukushima W;Sasaki S;Tsuboi Y;Yamada T;Oeda T;Shimada H;Kawamura N;Sakae N;Fukuyama H;Hirota Y;Nagai M;Fukuoka Kinki Parkinson's Disease Study Group
帕金森病（PD）的特征在于多巴胺能神经传递的改变。多巴胺能神经传递的遗传多态性可能影响PD的易感性。我们研究了儿茶酚-O-甲基转移酶（COMT）、单胺氧化酶B（MAOB）、多巴胺受体（DR）D2和DRD 4多态性与PD风险的关系，特别关注了238例PD患者和369例日本对照人群中吸烟的相互作用。与AG和GG基因型组合相比，MAOB rs 1799836的AA基因型受试者显示出显著增加的PD风险（比值比（OR）= 1.70，95%置信区间（CI）= 1.12 - 2.58）。与GG基因型相比，COMT rs 4680的AA基因型与PD风险增加略有相关（OR = 1.86，95%CI = 0.98 - 3.50）。DRD 2 rs 1800497和DRD 4 rs 1800955多态性与PD无关。提示COMT -吸烟相互作用，rs 4680的GA和AA基因型和不吸烟的组合赋予比AA基因型和吸烟史显著更高的风险（OR = 3.97，95%CI = 2.13 - 7.41）（相互作用的P = 0.061）。没有观察到吸烟与其他多态性的相互作用。COMT rs 4680和MAOB rs 1799836多态性可能增加日本人对PD风险的易感性。未来的研究涉及更大的控制和病例人群和更好的农药暴露史，无疑将导致更彻底的了解参与多巴胺通路的多态性在PD中的作用。
Parkinson's disease (PD) is characterized by alterations in dopaminergic neurotransmission. Genetic polymorphisms involved in dopaminergic neurotransmission may influence susceptibility to PD. We investigated the relationship of catechol-O-methyltransferase (COMT), monoamine oxidase B (MAOB), dopamine receptor (DR) D2 and DRD4 polymorphisms and PD risk with special attention to the interaction with cigarette smoking among 238 patients with PD and 369 controls in a Japanese population. Subjects with the AA genotype of MAOB rs1799836 showed a significantly increased risk of PD (odds ratio (OR) = 1.70, 95% confidence interval (CI) = 1.12 - 2.58) compared with the AG and GG genotypes combined. The AA genotype of COMT rs4680 was marginally associated with an increased risk of PD (OR = 1.86, 95% CI = 0.98 - 3.50) compared with the GG genotype. The DRD2 rs1800497 and DRD4 rs1800955 polymorphisms showed no association with PD. A COMT -smoking interaction was suggested, with the combined GA and AA genotypes of rs4680 and non-smoking conferring significantly higher risk (OR = 3.97, 95% CI = 2.13 - 7.41) than the AA genotype and a history of smoking (P for interaction = 0.061). No interactions of smoking with other polymorphisms were observed. The COMT rs4680 and MAOB rs1799836 polymorphisms may increase susceptibility to PD risk among Japanese. Future studies involving larger control and case populations and better pesticide exposure histories will undoubtedly lead to a more thorough understanding of the role of the polymorphisms involved in the dopamine pathway in PD.
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影响因子：
2.5
作者：
Gu, Zhuqin;Feng, Xiuli;Chan, Piu
通讯作者：
Chan, Piu
影响因子：
3.4
作者：
Kelada, SN;Costa-Mallen, P;Checkoway, H
通讯作者：
Checkoway, H
影响因子：
11.2
作者：
KURTH, JH;KURTH, MC;SCHWANKHAUS, JD
通讯作者：
SCHWANKHAUS, JD
DOI：
10.1006/bbrc.1996.1731
发表时间：
1996-11-21
影响因子：
3.1
作者：
Hoda, F;Nicholl, D;Collier, DA
通讯作者：
Collier, DA
影响因子：
11
作者：
Costa-Mallen, P;Costa, LG;Checkoway, H
通讯作者：
Checkoway, H