Force of lifelong crystalline lens growth: chronic traumatic mechanical insult to the choroid.
Force of lifelong crystalline lens growth: chronic traumatic mechanical insult to the choroid.
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DOI：
10.1097/j.jcrs.0000000000000744
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发表时间：
2022-03-01
影响因子：
2.8
通讯作者：
Strenk SA
中科院分区：
文献类型：
--
作者：
Strenk LM;Guo S;Lu K;Werner L;Strenk SA
计算由于晶状体终生生长而施加到葡萄膜和视网膜的力。回顾性研究。 MRI Research, Inc.，米德尔堡高地，俄亥俄州，美国； UMDNJ-新泽西医学院眼科和视觉科学研究所，新泽西州纽瓦克； USC 心理学 南加州大学，洛杉矶，加利福尼亚州。从白内障患者（46-83 岁）的 15 对有晶状体眼/假晶状体眼眼中获取磁共振图像。测量脉络膜长度。计算产生有晶状体眼/假晶状体眼脉络膜长度差异所需的力。与相应的人工晶状体眼相比，有晶状体眼的脉络膜长度更长，并且这种差异随着年龄的增长而增加（P = 0.00006；功效 = 0.99）。相应的脉络膜应变也随着年龄的增长而增加（P = 0.00003，功效 = 0.99），产生脉络膜长度变化所需的力也随之增加（P = 0.000008，功效 = 0.99）。我们推测，终生晶状体生长会对葡萄膜和视网膜造成慢性、创伤性、机械性损伤。这种以前未知的、不断增加的力似乎会拉伸脉络膜组织，并且可能是视网膜疾病的独立于眼压的可改变危险因素。对于了解经常与白内障共存的老化眼睛视网膜疾病的病理生理学具有重要意义，例如青光眼、黄斑变性和糖尿病视网膜病变。
To calculate the forces applied to uvea and retina as a result of lifelong crystalline lens growth. Retrospective Study. MRI Research, Inc., Middleburg Heights, Ohio, USA; Institute of Ophthalmology and Visual Science UMDNJ-New Jersey Medical School, Newark, New Jersey; USC Psychology University of Southern California, Los Angeles CA. Magnetic resonance images were acquired from 15 phakic/pseudophakic eye pairs in cataract patients (ages 46–83). Choroidal lengths were measured. The forces required to produce differences between phakic/pseudophakic choroidal lengths were calculated. The length of the choroid is greater in the phakic eye compared to the corresponding pseudophakic eye and this difference increases with age (P = 0.00006; power = 0.99). The corresponding choroidal strain also increases with age (P = 0.00003, power = 0.99) as do the forces required to produce such a change in choroidal length (P=0.000008, power = 0.99). We theorize that lifelong crystalline lens growth applies a chronic, traumatic, mechanical insult to the uvea and retina. This previously unknown, ever-increasing, force appears to stretch the choroidal tissue and may be an intraocular pressure independent modifiable risk factor for retinal disease. Implications exist for understanding the pathophysiology of retinal diseases in the aging eye that are often co-morbid with cataracts, for example, glaucoma, macular degeneration and diabetic retinopathy.
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DOI：
10.1900/rds.2015.12.159
发表时间：
2015-03-01
期刊：
The review of diabetic studies : RDS
影响因子：
--
作者：
Jenkins, Alicia J;Joglekar, Mugdha V;Januszewski, Andrzej S
通讯作者：
Januszewski, Andrzej S
影响因子：
4.1
作者：
Boulton, M;Foreman, D;McLeod, D
通讯作者：
McLeod, D
影响因子：
17.8
作者：
Strenk, SA;Strenk, LM;Koretz, JF
通讯作者：
Koretz, JF
影响因子：
2.8
作者：
Strenk, Susan A.;Strenk, Lawrence M.;Guo, Suqin
通讯作者：
Guo, Suqin
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影响因子：
3.7
作者：
Oddone F;Roberti G;Micera A;Busanello A;Bonini S;Quaranta L;Agnifili L;Manni G
通讯作者：
Manni G