Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults.
Negative association between triglyceride glucose index and BMI-adjusted skeletal muscle mass index in hypertensive adults.
复制标题
高血压成年人中甘油三酸酯葡萄糖指数与BMI调整后的骨骼肌质量指数之间的负相关。
DOI：
10.1186/s12891-023-06700-7
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发表时间：
2023-07-13
影响因子：
2.3
通讯作者：
Yao, Wenming
中科院分区：
文献类型：
--
作者：
Zhu, Qingqing;Zhang, Ting;Cheang, Iokfai;Lu, Xinyi;Shi, Mengsha;Zhu, Xu;Liao, Shengen;Gao, Rongrong;Li, Xinli;Yao, Wenming
甘油三酯葡萄糖（TyG）指数是胰岛素抵抗的指标，通常与各种心血管疾病的不良结局相关，而高血压与心血管疾病风险增加相关。由于对高血压患者肌肉质量的损失了解甚少，本研究旨在探讨高血压人群中TyG指数与肌肉质量的关系。我们分析了2011年至2018年国家健康和营养检查调查（NHANES）中高血压成年参与者的数据。计算TyG指数和体重指数（BMI）调整的骨骼肌质量指数（SMI），并使用多变量线性回归和限制性三次样条（RCS）回归模型评价两者之间的关系。数据集中共有1633名参与者被纳入最终分析。在多变量回归分析中，与最低四分位数相比，最高TyG指数四分位数的SMI的校正β（95%置信区间（CI））为− 5.27（− 9.79至− 0.75）。通过RCS回归绘制TyG指数与SMI之间的负线性关系（非线性P = 0.128）。不同年龄不吸烟女性分层模型也显示SMI随TyG指数的增加而降低（趋势P均< 0.05）。高血压患者TyG指数和SMI之间的线性和负相关性表明胰岛素抵抗对肌肉质量有不利影响。
The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertension is poorly understood, the current study aimed to explore the relationship between TyG index and muscle mass in hypertensive population. We analyzed data from hypertensive adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The TyG index and body mass index (BMI)-adjusted skeletal muscle mass index (SMI) were calculated and the relationship between the two was evaluated using multivariable linear regression and restricted cubic spline (RCS) regression models. A total of 1633 participants in the dataset were included for the final analysis. In the multivariable regression analysis, the adjusted β of SMI with a 95% confidence interval (CI) for the highest TyG index quartile was − 5.27 (− 9.79 to − 0.75), compared with the lowest quartile. A negative linear relationship between TyG index and SMI was plotted by RCS regression (nonlinear P = 0.128). Stratified models of non-smoking women of different ages also demonstrated that SMI decreased as TyG index increased (all P for trend < 0.05). This linear and negative correlation between TyG index and SMI in hypertensive patients suggests that insulin resistance adversely affects muscle mass.
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影响因子：
--
作者：
Abdul-Ghani MA;DeFronzo RA
通讯作者：
DeFronzo RA
影响因子：
9.3
作者：
Lu YW;Chang CC;Chou RH;Tsai YL;Liu LK;Chen LK;Huang PH;Lin SJ
通讯作者：
Lin SJ
影响因子：
5.1
作者：
Lee, Sang-Guk;Yim, Ye Seal;Kim, Jeong-Ho
通讯作者：
Kim, Jeong-Ho
影响因子：
3.7
作者：
Han K;Park YM;Kwon HS;Ko SH;Lee SH;Yim HW;Lee WC;Park YG;Kim MK;Park YM
通讯作者：
Park YM
影响因子：
13.8
作者：
Bao, Wei;Liu, Buyun;Lehmler, Hans-Joachim
通讯作者：
Lehmler, Hans-Joachim