Sarcopenia as a determinant of blood pressure in older Koreans: findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008-2010.
Sarcopenia as a determinant of blood pressure in older Koreans: findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) 2008-2010.
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DOI：
10.1371/journal.pone.0086902
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Park YM
中科院分区：
文献类型：
--
作者：
Han K;Park YM;Kwon HS;Ko SH;Lee SH;Yim HW;Lee WC;Park YG;Kim MK;Park YM
在普通人群中，血压(BP)与身体大小直接相关。肌肉质量是否是决定血压的重要因素仍不清楚。调查老年韩国人的骨肉减少是否与高血压有关。我们调查了2,099名男性和2,747名女性，年龄在60岁或以上。骨质疏松症被定义为附件骨骼肌重除以体重(ASM/Wt)，低于青壮年性别平均值。肥胖定义为体重指数(BMI)≥为25 kg/m2。受试者根据是否有肥胖或骨质疏松症被分成四组。高血压定义为收缩压(SBP)≥140毫米汞柱、舒张压≥(舒张压)90毫米汞柱或自我报告的当前使用的降压药。非肥胖性非骨质疏松症高血压患病率为49.7%，非肥胖性骨质疏松症高血压患病率为60.9%，肥胖性非骨质疏松症高血压患病率为66.2%，肥胖性骨质疏松症患病率为74.7%。在调整了年龄、性别、经常活动、当前吸烟和饮酒后，与非肥胖性骨质疏松症组相比，非肥胖性骨质疏松症组患高血压的优势比(OR)分别为1.5%(95%可信区间 = 1.23~1.84)、2.08(95%CI = 1.68~2.57)和3.0(95%CI = 2.48~3.63)，与非肥胖性骨质疏松症组相比(P<0.001)。进一步控制体重和腰围并不能改变高血压和骨质疏松症之间的联系。在患有糖尿病的受试者中，骨质疏松症与高血压之间的关系更为密切。体重指数以外的身体成分对韩国老年人的高血压有相当大的影响。与单纯肥胖或骨质疏松症患者相比，骨质疏松症患者患高血压的风险似乎更大。
Blood pressure (BP) is directly and causally associated with body size in the general population. Whether muscle mass is an important factor that determines BP remains unclear. To investigate whether sarcopenia is associated with hypertension in older Koreans. We surveyed 2,099 males and 2,747 females aged 60 years or older. Sarcopenia was defined as an appendicular skeletal muscle mass divided by body weight (ASM/Wt) that was <1 SD below the gender-specific mean for young adults. Obesity was defined as a body mass index (BMI) ≥25 kg/m2. Subjects were divided into four groups based on presence or absence of obesity or sarcopenia. Hypertension was defined as a systolic BP (SBP) ≥140 mmHg, a diastolic BP (DBP) ≥90 mmHg, or a self-reported current use of antihypertensive medications. The overall prevalence of hypertension in the four groups was as follows 49.7% for non-obese non-sarcopenia, 60.9% for non-obese sarcopenia, 66.2% for obese non-sarcopenia and 74.7% for obese sarcopenia. After adjustment for age, gender, regular activity, current smoking and alcohol use, the odds ratio (OR) for having hypertension was 1.5 (95% confidence interval (CI) = 1.23–1.84) in subjects in the non-obese sarcopenia group, 2.08 (95% CI = 1.68–2.57) in the obese non-sarcopenia group and 3.0 (95% CI = 2.48–3.63) in the obese sarcopenia group, compared with the non-obese non-sarcopenia group (p for trend <0.001). Controlling further for body weight and waist circumference did not change the association between hypertension and sarcopenia. The association between sarcopenia and hypertension was more robust in the subjects with diabetes mellitus. Body composition beyond BMI has a considerable impact on hypertension in elderly Koreans. Subjects with sarcopenic obesity appear to have a greater risk of hypertension than simply obese or sarcopenia subjects.
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