Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation.
Unexpected prolonged presentation of influenza antigens promotes CD4 T cell memory generation.
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DOI：
10.1084/jem.20050227
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发表时间：
2005-09-05
期刊：
影响因子：
--
通讯作者：
Swain SL
中科院分区：
文献类型：
--
作者：
Jelley-Gibbs DM;Brown DM;Dibble JP;Haynes L;Eaton SM;Swain SL
流感病毒衍生抗原（Ag）的呈递动力学，导致CD 4 T细胞效应和记忆产生，仍然不确定。在流感感染后的不同时间将初始流感特异性CD 4 T细胞转移到小鼠中，以确定病毒衍生的Ag呈递的持续时间和影响。即使在病毒清除后3-4周转移供体T细胞时，也产生Ag特异性T细胞应答。在感染的早期阶段，初始CD 4 T细胞的转移导致高度分化的效应子的稳健扩增，然后收缩为少量的记忆T细胞。重要的是，在感染后期的T细胞转移导致具有中间表型的效应子适度扩增，这些效应子能够以高效率作为记忆持续存在。因此，不同阶段的病原体来源的抗原呈递可能提供了一种机制，通过这种机制产生T细胞异质性和维持不同的记忆子集。
The kinetics of presentation of influenza virus–derived antigens (Ags), resulting in CD4 T cell effector and memory generation, remains undefined. Naive influenza-specific CD4 T cells were transferred into mice at various times after influenza infection to determine the duration and impact of virus-derived Ag presentation. Ag-specific T cell responses were generated even when the donor T cells were transferred 3–4 wk after viral clearance. Transfer of naive CD4 T cells during early phases of infection resulted in a robust expansion of highly differentiated effectors, which then contracted to a small number of memory T cells. Importantly, T cell transfer during later phases of infection resulted in a modest expansion of effectors with intermediate phenotypes, which were capable of persisting as memory with high efficiency. Thus, distinct stages of pathogen-derived Ag presentation may provide a mechanism by which T cell heterogeneity is generated and diverse memory subsets are maintained.
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DOI：
10.1084/jem.182.5.1591
发表时间：
1995-11-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Constant S;Pfeiffer C;Woodard A;Pasqualini T;Bottomly K
通讯作者：
Bottomly K
II类（I-AK/I-EK）限制性T细胞库的多样性，用于流感血凝素和抗原漂移。 HA1亚基上的六个非重叠表位是由合成肽定义的。
影响因子：
15.3
作者：
BURT, DS;MILLS, KHG;SKEHEL, JJ;THOMAS, DB
通讯作者：
THOMAS, DB
在B淋巴细胞缺陷小鼠中对致命流感病毒感染的抗性和恢复。
影响因子：
15.3
作者：
Graham, M B;Braciale, T J
通讯作者：
Braciale, T J
影响因子：
4.4
作者：
Harari, A;Vallelian, F;Pantaleo, G
通讯作者：
Pantaleo, G
影响因子：
32.4
作者：
Bird, JJ;Brown, DR;Reiner, SL
通讯作者：
Reiner, SL