Cortical thinning in patients with recent onset post-traumatic stress disorder after a single prolonged trauma exposure.
Cortical thinning in patients with recent onset post-traumatic stress disorder after a single prolonged trauma exposure.
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近期发生创伤后应激障碍的患者在一次长期创伤暴露后皮质变薄
DOI：
10.1371/journal.pone.0039025
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Yin H
中科院分区：
文献类型：
--
作者：
Liu Y;Li YJ;Luo EP;Lu HB;Yin H
目前关于创伤后应激障碍（PTSD）的磁共振成像（MRI）研究主要集中在测量小的脑结构体积或局部脑体积的变化。有罕见的报告调查皮质厚度的变化，在最近发病的创伤后应激障碍。计算分析的最新进展使得以全自动的方式测量皮质厚度成为可能，沿着基于体素的形态测量（VBM），其使得能够通过将统计参数映射（SPM）应用于高分辨率MRI来探索整个大脑的全局结构变化。本文在SPM下对MR图像进行自动分割后，利用Laplacian方法估计皮质厚度。然后用SPM 8软件对厚度图进行分析。比较10名矿工幸存者与最近发生的PTSD和10名幸存者没有PTSD从相同的创伤表明皮质变薄，左顶叶，右额下回，和右海马旁回。PTSD患者右侧额下回皮质厚度与CAPS评分呈显著负相关。我们的研究表明，形状相关的皮质厚度分析可能比体积分析更敏感的PTSD早期阶段的细微变化。
Most of magnetic resonance imaging (MRI) studies about post-traumatic stress disorder (PTSD) focused primarily on measuring of small brain structure volume or regional brain volume changes. There were rare reports investigating cortical thickness alterations in recent onset PTSD. Recent advances in computational analysis made it possible to measure cortical thickness in a fully automatic way, along with voxel-based morphometry (VBM) that enables an exploration of global structural changes throughout the brain by applying statistical parametric mapping (SPM) to high-resolution MRI. In this paper, Laplacian method was utilized to estimate cortical thickness after automatic segmentation of gray matter from MR images under SPM. Then thickness maps were analyzed by SPM8. Comparison between 10 survivors from a mining disaster with recent onset PTSD and 10 survivors without PTSD from the same trauma indicates cortical thinning in the left parietal lobe, right inferior frontal gyrus, and right parahippocampal gyrus. The regional cortical thickness of the right inferior frontal gyrus showed a significant negative correlation with the CAPS score in the patients with PTSD. Our study suggests that shape-related cortical thickness analysis may be more sensitive than volumetric analysis to subtle alteration at early stage of PTSD.
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