Evaluation of flicker induced hyperemia in the retina and optic nerve head measured by Laser Speckle Flowgraphy.
Evaluation of flicker induced hyperemia in the retina and optic nerve head measured by Laser Speckle Flowgraphy.
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DOI：
10.1371/journal.pone.0207525
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Garhöfer G
中科院分区：
文献类型：
--
作者：
Fondi K;Bata AM;Luft N;Witkowska KJ;Werkmeister RM;Schmidl D;Bolz M;Schmetterer L;Garhöfer G
神经活动与血流的耦合是眼血流调节的重要生理学原理。本研究旨在研究激光散斑血流图（LSFG）（一种用于测量血流的市售技术）是否能够评估闪烁引起的视网膜和视神经乳头（ONH）循环中的血流动力学变化。本横断面研究纳入了20例健康受试者。商业LSFG仪器用于测量ONH处以及在用闪烁光刺激之前和期间的视网膜血管中的血流。获得ONH的平均模糊率（MBR）（相对血流速度的量度）和相对流量（RFV）（相应视网膜血管的相对血流的量度）。闪烁光刺激使ONH MBR增加+17.5%至6.6%（p<0.01）。在视网膜动脉中，闪烁刺激导致总RFV增加+23.8 10. 0%（p<0.05）。对于视网膜静脉，在刺激期间观察到总RFV增加+23.1%的11.0（p<0.05）。在视网膜动脉（鼻侧：+28.9%<$20.0%;颞侧：+20.4%<$17.6%，p<0.05）和静脉（鼻侧：+28.3%<$19.6%;颞侧：+17.8%<$18.9%，p<0.05）中，鼻侧RFV的反应高于颞侧RFV。如先前用其他技术所示，闪烁刺激导致视网膜和视神经头血流的增加。我们的研究结果表明，LSFG是一种合适的方法，用于定量的视网膜和ONH血流在视觉刺激，并可用作一种非侵入性的，易于使用的工具，以评估在人类的神经血管耦合。
The coupling between neural activity and blood flow is a physiological key principle of ocular blood flow regulation. The current study was performed to investigate whether Laser speckle flowgraphy (LSFG), a commercially available technique for measuring blood flow, is capable to assess flicker-induced haemodynamic changes in the retinal and optic nerve head (ONH) circulation. Twenty healthy subjects were included in this cross sectional study. A commercial LSFG instrument was used to measure blood flow at the ONH as well as in retinal vessels before and during stimulation with flickering light. Mean blur rate (MBR), a measure of relative blood flow velocity, was obtained for the ONH and relative flow volume (RFV) a measure of relative blood flow of the respective retinal vessels. Stimulation with flicker light increased ONH MBR by +17.5%±6.6% (p<0.01). In retinal arteries, flicker stimulation led an increase of +23.8±10.0% (p<0.05) in total RFV. For retinal veins, an increase of +23.1%±11.0 (p<0.05) in total RFV was observed during stimulation. A higher response was observed in nasal RFV compared to temporal RFV in retinal arteries (nasal: +28.9%±20.0%; temporal: +20.4%±17.6%, p<0.05) and veins (nasal: +28.3%±19.6%; temporal +17.8%±18.9%, p<0.05). As shown previously with other techniques, flicker stimulation leads to an increase in retinal and optic nerve head blood flow. Our results indicate that LSFG is an appropriate method for the quantification of retinal and ONH blood flow during visual stimulation and may be used as a non-invasive, easy to use tool to assess neuro-vascular coupling in humans.
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散布亮度闪烁刺激期间，视网膜血流和视网膜征氧的关系的关系。
影响因子：
4.6
作者：
Palkovits S;Lasta M;Told R;Schmidl D;Werkmeister R;Cherecheanu AP;Garhöfer G;Schmetterer L
通讯作者：
Schmetterer L
影响因子：
17.8
作者：
Kur, Joanna;Newman, Eric A.;Chan-Ling, Tailoi
通讯作者：
Chan-Ling, Tailoi
影响因子：
4.4
作者：
Lasta, Michael;Pemp, Berthold;Schmetterer, Leopold
通讯作者：
Schmetterer, Leopold
影响因子：
4.1
作者：
Garhöfer, G;Zawinka, C;Dorner, GT
通讯作者：
Dorner, GT
影响因子：
8.3
作者：
Brueckmann, Andreas;Seeliger, Christin;Schlembach, Dietmar
通讯作者：
Schlembach, Dietmar