Elevated plasma IL-37, IL-18, and IL-18BP concentrations in patients with acute coronary syndrome.
Elevated plasma IL-37, IL-18, and IL-18BP concentrations in patients with acute coronary syndrome.
复制标题
急性冠脉综合征患者血浆 IL-37、IL-18 和 IL-18BP 浓度升高。
DOI：
10.1155/2014/165742
复制
发表时间：
2014
影响因子：
4.6
通讯作者：
Zhou Y
中科院分区：
文献类型：
--
作者：
Ji Q;Zeng Q;Huang Y;Shi Y;Lin Y;Lu Z;Meng K;Wu B;Yu K;Chai M;Liu Y;Zhou Y
目标。最近，有证据表明，新型抗炎细胞因子白细胞介素- (IL-) 37在动脉粥样硬化的冠状动脉和颈动脉斑块的泡沫样细胞中表达，表明IL-37参与动脉粥样硬化相关疾病。然而，急性冠状动脉综合征（ACS，包括不稳定型心绞痛和急性心肌梗死）患者的血浆IL-37水平尚未被研究。方法。测定50例稳定型心绞痛（SAP）患者、75例不稳定型心绞痛（UAP）患者、67例急性心肌梗死（AMI）患者和65例对照患者血浆IL-37、IL-18和IL-18BP水平。结果。与SAP和对照组相比，ACS患者血浆IL-37、IL-18和IL-18BP水平显著升高。相关分析显示血浆生物标志物水平与c反应蛋白（CRP）、n端脑钠肽前体（NT-proBNP）、左室舒张末期维数（LVEDD）呈正相关，与左室射血分数（LVEF）呈负相关。血浆IL-37、IL-18、IL-18BP与冠状动脉狭窄程度无相关性。结论。结果提示血浆IL-37水平与ACS发病相关。
Objective. More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in the foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting that IL-37 is involved in atherosclerosis-related diseases. However, the plasma levels of IL-37 in patients with acute coronary syndrome (ACS, including unstable angina pectoris and acute myocardial infarction) have yet to be investigated. Methods. Plasma IL-37, IL-18, and IL-18BP levels were measured in 50 patients with stable angina pectoris (SAP), 75 patients with unstable angina pectoris (UAP), 67 patients with acute myocardial infarction (AMI), and 65 control patients. Results. The plasma IL-37, IL-18, and IL-18BP levels were significantly increased in ACS patients compared to SAP and control patients. A correlation analysis showed that the plasma biomarker levels were positively correlated with each other and with the levels of C-reactive protein (CRP), N-terminal probrain natriuretic peptide (NT-proBNP), and left ventricular end-diastolic dimension (LVEDD) but negatively correlated with left ventricular ejection fraction (LVEF). Furthermore, the plasma IL-37, IL-18, and IL-18BP had no correlation with the severity of the coronary artery stenosis. Conclusions. The results indicate that the plasma IL-37 levels are associated with the onset of ACS.
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DOI：
10.1161/01.atv.0000147126.99529.0a
发表时间：
2004-12-01
影响因子：
8.7
作者：
de Nooijer, R;von der Thüsen, JH;Biessen, EAL
通讯作者：
Biessen, EAL
血浆 IL-35 水平降低与冠状动脉疾病中的左心室射血分数相关
影响因子：
3.7
作者：
Lin Y;Huang Y;Lu Z;Luo C;shi Y;Zeng Q;Cao Y;Liu L;Wang X;Ji Q
通讯作者：
Ji Q
影响因子：
37.8
作者：
Mallat, Z;Corbaz, A;Tedgui, A
通讯作者：
Tedgui, A
DOI：
10.1073/pnas.212519099
发表时间：
2002-10-15
影响因子：
11.1
作者：
Bufler, P;Azam, T;Kim, SH
通讯作者：
Kim, SH
慢性乙型肝炎患者替比夫定治疗期间血清白细胞介素 37 浓度和 HBeAg 血清转化
影响因子：
2.3
作者：
Li, Cong;Ji, Huifan;Jiang, Yanfang
通讯作者：
Jiang, Yanfang