Synthesis, structure and antimicrobial property of green composites from cellulose, wool, hair and chicken feather.
Synthesis, structure and antimicrobial property of green composites from cellulose, wool, hair and chicken feather.
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纤维素、羊毛、毛发、鸡毛绿色复合材料的合成、结构及抗菌性能。
DOI：
10.1016/j.carbpol.2016.06.021
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发表时间：
2016
影响因子：
11.2
通讯作者：
Benzi,Gerald
中科院分区：
文献类型：
--
作者：
Tran,ChieuD;Prosenc,Franja;Franko,Mladen;Benzi,Gerald
以离子液体氯化丁基甲基咪唑（BMIm+Cl−）为唯一溶剂，采用一步法合成了纤维素（CEL）与角蛋白（KER）的复合材料。该方法是绿色和可回收的，因为使用的[BMIm+Cl−]被回收再利用。光谱（FTIR，XRD）和成像（SEM）的结果证实，CEL和KER保持化学完整和均匀地分布在复合材料中。KER在复合材料中保留了一些二级结构。有趣的是，羊毛、毛发和羽毛中KER结构的微小差异导致其相应复合物的构象的显著差异，其中羊毛具有最高的α-螺旋含量，羽毛具有最低的含量。这些结果与复合材料的机械和抗菌性能相关。具体地，将CEL添加到KER中显著提高了由所有三种不同来源（羊毛、毛发和鸡毛）制成的[CEL + KER]复合材料的机械强度，[CEL+羊毛]、[CEL +毛发]和[CEL +羽毛]。由于机械强度是由于CEL，并且CEL仅具有随机结构，因此[CEL +羽毛]具有最强的机械性能，因为羽毛具有最低的α-螺旋含量。相反，[CEL +羊毛]复合材料具有最弱的机械强度，因为羊毛具有最高的α-螺旋含量。三种复合物均表现出对耐甲氧西林金黄色葡萄球菌（MRSA）的抗菌活性。抗菌性能不是由于CEL而是由于蛋白质，并且强烈地取决于角蛋白的类型，即，羽毛的杀菌效果最强，羊毛的杀菌效果最弱。这些结果连同我们先前的发现，即[CEL + KER]复合材料可以控制药物如环丙沙星的释放，清楚地表明这些复合材料可以潜在地用作伤口敷料。
Novel composites between cellulose (CEL) and keratin (KER) from three different sources (wool, hair and chicken feather) were successfully synthesized in a simple one-step process in which butylmethylimidazolium chloride (BMIm+Cl−), an ionic liquid, was used as the sole solvent. The method is green and recyclable because [BMIm+Cl−] used was recovered for reuse. Spectroscopy (FTIR, XRD) and imaging (SEM) results confirm that CEL and KER remain chemically intact and homogeneously distributed in the composites. KER retains some of its secondary structure in the composites. Interestingly, the minor differences in the structure of KER in wool, hair and feather produced pronounced differences in the conformation of their corresponding composites with wool has the highest α-helix content and feather has the lowest content. These results correlate well with mechanical and antimicrobial properties of the composites. Specifically, adding CEL into KER substantially improves mechanical strength of [CEL + KER] composites made from all three different sources, wool, hair and chicken feathers i.e., [CEL + wool], [CEL + hair] and [CEL + feather]. Since mechanical strength is due to CEL, and CEL has only random structure, [CEL + feather] has, expectedly, the strongest mechanical property because feather has the lowest content of α-helix. Conversely, [CEL + wool] composite has the weakest mechanical strength because wool has the highest α-helix content. All three composites exhibit antibacterial activity against methicillin resistantStaphylococcus aureus(MRSA). The antibacterial property is due not to CEL but to the protein and strongly depends on the type of the keratin, namely, the bactericidal effect is strongest for feather and weakest for wool. These results together with our previous finding that [CEL + KER] composites can control release of drug such as ciprofloxacin clearly indicate that these composites can potentially be used as wound dressing.
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