Optical assessment of tumor resection margins in the breast.
Optical assessment of tumor resection margins in the breast.
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DOI：
10.1109/jstqe.2009.2033257
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发表时间：
2010-03-01
期刊：
影响因子：
--
通讯作者：
Ramanujam N
中科院分区：
文献类型：
--
作者：
Brown JQ;Bydlon TM;Richards LM;Yu B;Kennedy SA;Geradts J;Wilke LG;Junker M;Gallagher J;Barry W;Ramanujam N
保乳手术切除乳腺肿瘤和周围正常组织，是治疗浸润性和原位乳腺癌的主要方式，每年影响近 200,000 名女性。在这近20万名接受该手术的患者中，由于缺乏可以检测切除标本边界是否有残留癌症的术中工具，其中20-70%可能需要接受额外的手术以切除第一次手术中留下的肿瘤。光学技术具有许多吸引人的属性，这可能使其成为术中评估乳腺肿瘤切除边缘的有用工具。在这篇手稿中，我们讨论了术中乳腺肿瘤边缘评估的临床设计标准，并回顾了应用于该问题的光学技术。此外，我们还报告了定量漫反射成像 (Q-DRI) 的开发和临床测试，作为满足这一临床需求的潜在解决方案。 Q-DRI 是一种光谱成像工具，已应用于杜克大学医学中心 48 名患者的 56 个切除边缘。该设备可识别癌性切除边缘和无癌切除边缘之间的清晰对比源，检测阳性边缘的总体准确度为 75%。
Breast conserving surgery, in which the breast tumor and surrounding normal tissue are removed, is the primary mode of treatment for invasive and in situ carcinomas of the breast, conditions that affect nearly 200,000 women annually. Of these nearly 200,000 patients who undergo this surgical procedure, between 20–70% of them may undergo additional surgeries to remove tumor that was left behind in the first surgery, due to the lack of intra-operative tools which can detect whether the boundaries of the excised specimens are free from residual cancer. Optical techniques have many attractive attributes which may make them useful tools for intra-operative assessment of breast tumor resection margins. In this manuscript, we discuss clinical design criteria for intra-operative breast tumor margin assessment, and review optical techniques appied to this problem. In addition, we report on the development and clinical testing of quantitative diffuse reflectance imaging (Q-DRI) as a potential solution to this clinical need. Q-DRI is a spectral imaging tool which has been applied to 56 resection margins in 48 patients at Duke University Medical Center. Clear sources of contrast between cancerous and cancer-free resection margins were identified with the device, and resulted in an overall accuracy of 75% in detecting positive margins.
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影响因子：
3.5
作者：
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通讯作者：
Saunders, C
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3.5
作者：
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通讯作者：
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