Unusual influenza A viruses in bats.

Unusual influenza A viruses in bats.
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DOI:
10.3390/v6093438
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发表时间:
2014-09-17
期刊:
Viruses
影响因子:
--
通讯作者:
Mehle A
Mehle A
中科院分区:
其他
文献类型:
--
作者:
Mehle A

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甲型流感病毒感染的宿主数量非常多样化。最近在蝙蝠中发现了两种全新的甲型流感病毒亚型,极大地扩大了该病毒的宿主范围。这些蝙蝠病毒与所有其他已知毒株极为不同,可能具有独特的复制周期。系统发育分析表明蝙蝠有长期的、孤立的进化。在取样的蝙蝠种群中有很高的血清流行率支持了这一点。由于蝙蝠占所有分类哺乳动物的约20%,因此这些发现表明存在大量未明确特征的甲型流感病毒的隐藏库。在这里,我们回顾了在了解这些新发现的病毒方面取得的令人兴奋的进展,并讨论了它们的人畜共患潜力。
Influenza A viruses infect a remarkably diverse number of hosts. Two completely new influenza A virus subtypes were recently discovered in bats, dramatically expanding the host range of the virus. These bat viruses are extremely divergent from all other known strains and likely have unique replication cycles. Phylogenetic analysis indicates long-term, isolated evolution in bats. This is supported by a high seroprevalence in sampled bat populations. As bats represent ~20% of all classified mammals, these findings suggests the presence of a massive cryptic reservoir of poorly characterized influenza A viruses. Here, we review the exciting progress made on understanding these newly discovered viruses, and discuss their zoonotic potential.
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影响因子: 6.7
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