Bats host major mammalian paramyxoviruses.
Bats host major mammalian paramyxoviruses.
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DOI：
10.1038/ncomms1796
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发表时间：
2012-04-24
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
副粘病毒科的大病毒家族包括一些最重要的人类和牲畜病毒，如麻疹病毒、犬瘟热病毒、腮腺炎病毒、副流感病毒、纽卡斯尔病病毒、呼吸道合胞病毒和偏肺病毒。在这里，我们确定了估计66个新的副粘病毒在全球样本的119蝙蝠和啮齿动物物种（9,278个人）。重大发现包括亨德拉病毒和尼帕病毒起源于非洲的证据，与人类腮腺炎病毒同种的蝙蝠病毒的鉴定，在蝙蝠中检测到呼吸道合胞病毒，小鼠肺炎和犬瘟热病毒的近亲，以及啮齿动物中仙台病毒的直接证据。宿主协会的系统发育重建表明，从蝙蝠到其他哺乳动物和鸟类的主机开关占主导地位。假设检验的最大似然框架允许的系统发育放置蝙蝠作为暂定主机在祖先节点的两个主要的副粘病毒亚科（副粘病毒亚科和肺炎病毒亚科）。未来预测人类和牲畜中新副粘病毒出现的尝试将不得不从根本上依赖于这些数据。本文的在线版本（doi：10.1038/ncomms 1796）包含补充材料，授权用户可以使用。副粘病毒科是一个大的病毒家族，包括几种人类和牲畜病毒。这项研究测试了分布在全球的119种蝙蝠和啮齿动物，确定了新的推定副粘病毒种属，为预测人类和牲畜中新副粘病毒的出现提供了潜在用途的数据。本文的在线版本（doi：10.1038/ncomms 1796）包含补充材料，授权用户可以使用。
The large virus family Paramyxoviridae includes some of the most significant human and livestock viruses, such as measles-, distemper-, mumps-, parainfluenza-, Newcastle disease-, respiratory syncytial virus and metapneumoviruses. Here we identify an estimated 66 new paramyxoviruses in a worldwide sample of 119 bat and rodent species (9,278 individuals). Major discoveries include evidence of an origin of Hendra- and Nipah virus in Africa, identification of a bat virus conspecific with the human mumps virus, detection of close relatives of respiratory syncytial virus, mouse pneumonia- and canine distemper virus in bats, as well as direct evidence of Sendai virus in rodents. Phylogenetic reconstruction of host associations suggests a predominance of host switches from bats to other mammals and birds. Hypothesis tests in a maximum likelihood framework permit the phylogenetic placement of bats as tentative hosts at ancestral nodes to both the major Paramyxoviridae subfamilies (Paramyxovirinae and Pneumovirinae). Future attempts to predict the emergence of novel paramyxoviruses in humans and livestock will have to rely fundamentally on these data. The online version of this article (doi:10.1038/ncomms1796) contains supplementary material, which is available to authorized users. The large virus family,Paramyxoviridae, includes several human and livestock viruses. This study, testing 119 bat and rodent species distributed globally, identifies novel putative paramyxovirus species, providing data with potential uses in predictions of the emergence of novel paramyxoviruses in humans and livestock. The online version of this article (doi:10.1038/ncomms1796) contains supplementary material, which is available to authorized users.
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影响因子：
11.8
作者：
Drexler JF;Corman VM;Wegner T;Tateno AF;Zerbinati RM;Gloza-Rausch F;Seebens A;Müller MA;Drosten C
通讯作者：
Drosten C
影响因子：
15.8
作者：
Drexler, Jan Felix;Kupfer, Bernd;Petersen, Nadine;Tommasini Grotto, Rejane Maria;Corvino Rodrigues, Silvia Maria;Grywna, Klaus;Panning, Marcus;Annan, Augustina;Silva, Giovanni Faria;Douglas, Jill;Koay, Evelyn S. C.;Smuts, Heidi;Netto, Eduardo M.;Simmonds, Peter;de Moura Campos Pardini, Maria Ines;Roth, W. Kurt;Drosten, Christian
通讯作者：
Drosten, Christian
影响因子：
64.8
作者：
Gao, F;Bailes, E;Hahn, BH
通讯作者：
Hahn, BH
影响因子：
64.8
作者：
Jones KE;Patel NG;Levy MA;Storeygard A;Balk D;Gittleman JL;Daszak P
通讯作者：
Daszak P
影响因子：
11.8
作者：
Formenty P;Muntasir MO;Damon I;Chowdhary V;Opoka ML;Monimart C;Mutasim EM;Manuguerra JC;Davidson WB;Karem KL;Cabeza J;Wang S;Malik MR;Durand T;Khalid A;Rioton T;Kuong-Ruay A;Babiker AA;Karsani ME;Abdalla MS
通讯作者：
Abdalla MS