Tumor-tropic Trojan horses: Using mesenchymal stem cells as cellular nanotheranostics.
Tumor-tropic Trojan horses: Using mesenchymal stem cells as cellular nanotheranostics.
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DOI：
10.7150/thno.90187
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发表时间：
2024
期刊：
影响因子：
12.4
通讯作者：
Shakeri-Zadeh A
中科院分区：
文献类型：
--
作者：
Rosu A;Ghaemi B;Bulte JWM;Shakeri-Zadeh A
各种类型的纳米抗肿瘤药物已经被开发出来，用于增强肿瘤成像和治疗。然而，成功使用纳米抗肿瘤药物的关键限制包括其靶向性、有限的非部位组织积累以及它们在整个肿瘤中的分布和长期滞留。由于间充质干细胞(MSCs)固有的亲肿瘤特性，最近有人建议将其用作“特洛伊木马”，以更有效地传递纳米抗肿瘤药物。这篇综述讨论了在临床前癌症模型中用于联合(多模式)成像和治疗的“细胞纳米差异分析”的现状。重点是对MSC趋瘤的信号通路和分子机制的有限了解，以及如何利用这些信息来利用这些信息来设计MSCs，以便进一步利用图像引导的程序来改善肿瘤的归巢和纳米消融输送。
Various classes of nanotheranostics have been developed for enhanced tumor imaging and therapy. However, key limitations for a successful use of nanotheranostics include their targeting specificity with limited off-site tissue accumulation as well as their distribution and prolonged retention throughout the entire tumor. Due to their inherent tumor-tropic properties, the use of mesenchymal stem cells (MSCs) as a “Trojan horse” has recently been proposed to deliver nanotheranostics more effectively. This review discusses the current status of “cellular nanotheranostics” for combined (multimodal) imaging and therapy in preclinical cancer models. Emphasis is placed on the limited knowledge of the signaling pathways and molecular mechanisms of MSC tumor-tropism, and how such information may be exploited to engineer MSCs in order to further improve tumor homing and nanotheranostic delivery using image-guided procedures.
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DOI：
10.1016/j.ymeth.2015.08.013
发表时间：
2016-04-15
期刊：
Methods (San Diego, Calif.)
影响因子：
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作者：
Bagó JR;Sheets KT;Hingtgen SD
通讯作者：
Hingtgen SD
影响因子：
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作者：
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影响因子：
15.9
作者：
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Semenza, Gregg L.
影响因子：
12.4
作者：
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Altaner, Cestmir
影响因子：
4.8
作者：
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