Analysis of the evolutionary forces shaping mitochondrial genomes of a Neotropical malaria vector complex.
Analysis of the evolutionary forces shaping mitochondrial genomes of a Neotropical malaria vector complex.
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DOI：
10.1016/j.ympev.2011.01.003
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发表时间：
2011-03
影响因子：
4.1
通讯作者：
Wilkerson, Richard C.
中科院分区：
文献类型：
--
作者：
Krzywinski, Jaroslaw;Li, Cong;Morris, Marion;Conn, Jan E.;Lima, Jose B.;Povoa, Marinete M.;Wilkerson, Richard C.
关键词：
人类疟疾的许多媒介属于形态上难以区分的隐蔽种的复合体。在这里，我们报告的新测序的完整的线粒体DNA分子的分析，从六个公认的或假定的物种的一个这样的组，新热带区按蚊albitarsis复杂。这些基因组的分子进化是由纯化选择驱动的，特别是对RNA基因的强烈作用。与链异步不对称mtDNA复制机制相关的定向突变压力可能在这些和其他按蚊物种的核苷酸组成中形成了明显的DNA链不对称性。序列多态性的分布，再加上冲突的系统发育树推断从线粒体DNA和从公布的白色基因片段序列，表明复杂的进化可能涉及古老的线粒体DNA渐渗。6个蛋白质编码基因（nad5，nad4，cox3，atp6，cox1和nad2）具有高度的序列差异，可能为群体遗传学研究提供信息。最后，该复合体内线粒体DNA的变异程度支持了这样的观点：该复合体由比直到最近认为的更多物种组成。
Many vectors of human malaria belong to complexes of morphologically indistinguishable cryptic species. Here we report the analysis of the newly sequenced complete mitochondrial DNA molecules from six recognized or putative species of one such group, the Neotropical Anopheles albitarsis complex. The molecular evolution of these genomes had been driven by purifying selection, particularly strongly acting on the RNA genes. Directional mutation pressure associated with the strand-asynchronous asymmetric mtDNA replication mechanism may have shaped a pronounced DNA strand asymmetry in the nucleotide composition in these and other Anopheles species. The distribution of sequence polymorphism, coupled with the conflicting phylogenetic trees inferred from the mitochondrial DNA and from the published white gene fragment sequences, indicates that the evolution of the complex may have involved ancient mtDNA introgression. Six protein coding genes (nad5, nad4, cox3, atp6, cox1 and nad2) have high levels of sequence divergence and are likely informative for population genetics studies. Finally, the extent of the mitochondrial DNA variation within the complex supports the notion that the complex consists of a larger number of species than until recently believed.
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