Prenatal DDT exposure in relation to anthropometric and pubertal measures in adolescent males.
Prenatal DDT exposure in relation to anthropometric and pubertal measures in adolescent males.
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产前滴滴涕暴露与青春期男性的人体测量和青春期测量相关。
DOI：
10.1289/ehp.7287
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发表时间：
2004-12
影响因子：
10.4
通讯作者：
Longnecker, MP
中科院分区：
文献类型：
--
作者：
Gladen, BC;Klebanoff, MA;Hediger, ML;Katz, SH;Barr, DB;Davis, MD;Longnecker, MP
滴滴涕（二氯二苯三氯乙烷）是一种曾经广泛用于农业的杀虫剂，现在仅限于公共卫生使用，由于其益处和风险的结合，仍然是一种有争议的化学品。滴滴涕或其分解产物在环境和人体内普遍存在。滴滴涕家族的化合物具有内分泌作用，并与生殖毒性有关。先前的一项研究报告了产前暴露于p，p′-DDE [1，1-二氯-2，2-双（对氯苯基）-乙烯]与青春期男孩身高和体重增加之间的关系。我们检查了一组暴露较高的人群，看看是否会发生类似的关联。我们的研究组是304名20世纪60年代初出生在费城的男性，他们参加了以前的研究。可获得青少年时期1至6次访问的人体测量和青春期测量结果，以及储存的妊娠期母体血清样本。我们测定了孕妇血清中的p，p′-DDE、p，p′-DDT [1，1，1-三氯-2，2-双（对氯苯基）-乙烷]和o，p′-DDT [1，1，1-三氯-2-（邻氯苯基）-2-（对氯苯基）-乙烷]。在男孩中检查的结果包括身高、坐高与身高的比值、体重指数、三头肌皮褶厚度、肩胛下与三头肌和肩胛下皮褶厚度之和的比值、骨龄、血清睾酮和血清硫酸脱氢表雄酮。产前暴露于任何滴滴涕化合物和任何结果测量之间没有联系。
DDT (dichlorodiphenyltrichloroethane), a pesticide once used widely in agriculture and now limited to public health use, remains a controversial chemical because of a combination of benefits and risks. DDT or its breakdown products are ubiquitous in the environment and in humans. Compounds in the DDT family have endocrine actions and have been associated with reproductive toxicity. A previous study reported associations between prenatal exposure to p,p′-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene] and increased height and weight in adolescent boys. We examined a group with higher exposures to see whether similar associations would occur. Our study group was 304 males born in Philadelphia in the early 1960s who had participated in a previous study. Anthropometric and pubertal measures from one to six visits during their adolescent years were available, as were stored maternal serum samples from pregnancy. We measured p,p′-DDE, p,p′-DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)-ethane], and o,p′-DDT [1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-ethane] in the maternal serum. Outcomes examined in the boys were height, ratio of sitting height to height, body mass index, triceps skinfold thickness, ratio of subscapular to the sum of triceps and subscapular skinfold thicknesses, skeletal age, serum testosterone, and serum dehydroepiandrosterone sulfate. No associations between prenatal exposure to any of the DDT compounds and any outcome measure were seen.
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影响因子：
1.8
作者：
Hosie, S;Loff, S;Waag, KL
通讯作者：
Waag, KL
影响因子：
3.8
作者：
Loeffler, IK;Peterson, RE
通讯作者：
Peterson, RE
DOI：
10.1080/00039890109604065
发表时间：
2001-03-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Hagmar, L;Björk, J;Erfurth, EM
通讯作者：
Erfurth, EM
影响因子：
5.6
作者：
Hardy, JB
通讯作者：
Hardy, JB
影响因子：
8.3
作者：
KATZ, SH;HEDIGER, ML;PARKS, JS
通讯作者：
PARKS, JS