Lessons from the past: opportunities to improve childhood cancer survivor care through outcomes investigations of historical therapeutic approaches for pediatric hematological malignancies.

Lessons from the past: opportunities to improve childhood cancer survivor care through outcomes investigations of historical therapeutic approaches for pediatric hematological malignancies.
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DOI:
10.1002/pbc.23385
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发表时间:
2012-03
影响因子:
3.2
通讯作者:
Green, Daniel M.
Green, Daniel M.
中科院分区:
医学3区
文献类型:
--
作者:
Hudson, Melissa M.;Neglia, Joseph P.;Woods, William G.;Sandlund, John T.;Pui, Ching-Hon;Kun, Larry E.;Robison, Leslie L.;Green, Daniel M.

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长期结果的研究有助于设计更安全和更有效的儿科血液恶性肿瘤的现代疗法。尽管在过去的五十年中发生了重大的治疗变化,但治疗修改在很大程度上代表了使用已超过30年的药物和方式的治疗方案的改进。本文综述了自1960年以来儿科恶性血液病治疗演变的主要趋势,以支持历史治疗方法的晚期效应研究与当代治疗方案的设计和评估以及当今幸存者的随访的相关性。
Investigations of long-term outcomes have been instrumental in designing safer and more effective contemporary therapies for pediatric hematological malignancies. Despite the significant therapeutic changes that have occurred over the last five decades, therapy modifications largely represent refinements of treatment protocols using agents and modalities that have been available for more than 30 years. This review summarizes major trends in the evolution of treatment of pediatric hematological malignancies since 1960 to support the relevance of the study of late effects of historical therapeutic approaches to the design and evaluation of contemporary treatment protocols and the follow-up of present-day survivors.
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