Individual behavioral differences in recovery from abdominal sepsis in rats
Individual behavioral differences in recovery from abdominal sepsis in rats
复制标题
大鼠腹部脓毒症恢复的个体行为差异
DOI：
10.1007/s00011-008-8223-2
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发表时间：
2009
影响因子：
6.7
通讯作者：
Pawlak C.R.
中科院分区：
文献类型：
--
作者：
Bauhofer A;Schwarting R.K.W;Schmitt A;Köster M;Lorenz W;Ho Y.J;Pawlak C.R.
目的和设计在本研究中，我们确定了个体行为差异(高和低活动)是否对高或低死亡率的脓毒症的康复有不同的影响。高死亡率试验1：将大鼠随机分为(1)对照组-A组：麻醉，(2)对照组-B：假手术，(3)脓毒症：剖腹手术和腹膜污染及人类粪便细菌感染(PCI)，(4)抗生素预防(头孢呋辛/甲硝唑)脓毒症，(5)抗生素+G-CSF预防脓毒症。低死亡率试验2：第3组和第5组的比较。终点是死亡率、行为(野外和社会互动试验)和促炎细胞因子(IL-6=IL-6和巨噬细胞炎性蛋白-2=MIP-2)。结果在两个试验中，联合使用抗生素和G-CSF在降低死亡率和改善疾病行为方面是最有效的。经统计学处理，G-CSF对行为缺陷的改善无统计学意义。然而，在两种行为测试中，高响应者和低响应者受到的影响不同。此外，IL-6和MIP-2在接种24小时后仅在未治疗和高死亡率的高应答者中升高。结论G-CSF/抗生素预防可改善脓毒症患者的疾病行为。脓毒症的康复过程可能取决于发病前的个体差异。
Objective and DesignIn the present study we determined whether individual behavioral differences (high and low locomotor activity) differentially affected recovery from sepsis with high or low mortality.MethodsTwo trials were performed. Trial 1 with high mortality: Rats were randomly assigned to (1) control-A: anesthesia, (2) control-B: sham surgery, (3) sepsis: laparotomy and peritoneal contamination and infection (PCI) with human stool bacteria, (4) sepsis with antibiotic prophylaxis (cefuroxime/ metronidazole), and (5) sepsis with antibiotic plus G-CSF prophylaxis. Trial 2 with low mortality: Comparison of groups 3 and 5. Endpoints were mortality, behavior (open field and social interaction tests), and proinflammatory cytokines (interleukin-6 = IL-6 and macrophage inflammatory protein-2 = MIP-2).ResultsThe combination of antibiotics plus G-CSF was most effective in reducing mortality in both trials and modified sickness behavior. Behavioral deficits were not statistically significantly improved by G-CSF. However, high versus low responders were differentially affected in both behavioral tests. Furthermore, IL-6 and MIP-2 were increased 24 hours after inoculum only in high responders with untreated sepsis and high mortality.ConclusionImprovement of sickness behavior in sepsis with G-CSF/antibiotic prophylaxis is a promising approach. The course of recovery from sepsis may depend on premorbid individual differences.
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影响因子：
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作者：
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期刊：
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