Long noncoding RNAs usher in a new era in the biology of enhancers.
Long noncoding RNAs usher in a new era in the biology of enhancers.
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DOI:
10.1016/j.cell.2013.08.028
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发表时间:
2013-09-12
期刊:
影响因子:
64.5
通讯作者:
Shiekhattar R
中科院分区:
文献类型:
--
作者:
Ørom UA;Shiekhattar R
The functional transcription of long noncoding RNAs is emerging as an important advance in our understanding of enhancers of transcription. Once expressed, enhancer-associated long noncoding RNAs can act over long distances, and across chromosomes, to activate transcription at distal promoters through association with protein factors and to modulate chromatin structure. Here, we address the latest advances made towards understanding the role of long noncoding RNAs expression and their involvement in enhancer function.
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