Mediators of reprogramming: transcription factors and transitions through mitosis.

Mediators of reprogramming: transcription factors and transitions through mitosis.
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重编程的介体:通过有丝分裂的转录因子和过渡。

DOI:
10.1038/nrm2439
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发表时间:
2008-07
期刊:
Nature reviews. Molecular cell biology
影响因子:
--
通讯作者:
Eggan K
Eggan K
中科院分区:
其他
文献类型:
--
作者:
Egli D;Birkhoff G;Eggan K

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It is thought that most cell types of the human body share the same genetic information as that contained in the zygote from which they originate. Consistent with this view, animal cloning studies demonstrated that the intact genome of a differentiated cell can be reprogrammed to support the development of an entire organism and allow the production of pluripotent stem cells. Recent progress in reprogramming research now points to an important role for transcription factors in the establishment and the maintenance of cellular phenotypes, and to cell division as a mediator of transitions between different states of gene expression.
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