Apportioning archaic variants among modern populations.
Apportioning archaic variants among modern populations.
复制标题
在现代人群中分配古老的变种。
DOI：
10.1098/rstb.2020.0411
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发表时间：
2022-06-06
影响因子：
6.3
通讯作者：
Huerta-Sanchez, Emilia
中科院分区：
文献类型：
--
作者：
Witt, Kelsey E.;Villanea, Fernando;Loughran, Elle;Zhang, Xinjun;Huerta-Sanchez, Emilia
人类遗传多样性在种群内和种群间的分配已被测量，以了解人类的亲缘关系和人口统计学历史。同样，现代人群中古代祖先的分布可以用来更好地理解我们这个物种与其古代亲属之间的相互作用。解决现代和古代人口之间的相互作用可能是困难的，因为现代人口中的古代变异是由遗传漂变、瓶颈和基因流动形成的。在这里，我们调查的分布在欧亚人群的古老的变化。我们发现，在个人和人口水平的古代祖先覆盖率在现代人群中呈现出独特的模式：南亚人与欧洲人或东亚人相比，具有近两倍的人口独特的古代等位基因，这表明这些人群经历了不同的人口和古代混合事件。我们证实了以前的观察结果，即东亚人比欧洲人有更多的尼安德特人祖先，但令人惊讶的是，当我们比较单核苷酸多态性与在人群中发现的古老等位基因的数量时，欧洲人比东亚人有更多的尼安德特人祖先。我们将这些结果与模拟模型进行比较，并得出结论，这些模式与现代人和尼安德特人之间的多个混合事件是一致的。这篇文章是主题问题的一部分，“庆祝Lewontin对人类多样性的分配50周年”。
The apportionment of human genetic diversity within and between populations has been measured to understand human relatedness and demographic history. Likewise, the distribution of archaic ancestry in modern populations can be leveraged to better understand the interaction between our species and its archaic relatives. Resolving the interactions between modern and archaic human populations can be difficult, as archaic variants in modern populations have been shaped by genetic drift, bottlenecks and gene flow. Here, we investigate the distribution of archaic variation in Eurasian populations. We find that archaic ancestry coverage at the individual- and population-level present distinct patterns in modern human populations: South Asians have nearly twice the number of population-unique archaic alleles compared with Europeans or East Asians, indicating that these populations experienced differing demographic and archaic admixture events. We confirm previous observations that East Asian individuals have more Neanderthal ancestry than European individuals, but surprisingly, when we compare the number of single nucleotide polymorphisms with archaic alleles found across a population, Europeans have more Neanderthal ancestry than East Asians. We compare these results to simulated models and conclude that these patterns are consistent with multiple admixture events between modern humans and Neanderthals. This article is part of the theme issue ‘Celebrating 50 years since Lewontin's apportionment of human diversity’.
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影响因子：
64.8
作者：
Lazaridis, Iosif;Patterson, Nick;Mittnik, Alissa;Renaud, Gabriel;Mallick, Swapan;Kirsanow, Karola;Sudmant, Peter H.;Schraiber, Joshua G.;Castellano, Sergi;Lipson, Mark;Berger, Bonnie;Economou, Christos;Bollongino, Ruth;Fu, Qiaomei;Bos, Kirsten I.;Nordenfelt, Susanne;Li, Heng;de Filippo, Cesare;Pruefer, Kay;Sawyer, Susanna;Posth, Cosimo;Haak, Wolfgang;Hallgren, Fredrik;Fornander, Elin;Rohland, Nadin;Delsate, Dominique;Francken, Michael;Guinet, Jean-Michel;Wahl, Joachim;Ayodo, George;Babiker, Hamza A.;Bailliet, Graciela;Balanovska, Elena;Balanovsky, Oleg;Barrantes, Ramiro;Bedoya, Gabriel;Ben-Ami, Haim;Bene, Judit;Berrada, Fouad;Bravi, Claudio M.;Brisighelli, Francesca;Busby, George B. J.;Cali, Francesco;Churnosov, Mikhail;Cole, David E. C.;Corach, Daniel;Damba, Larissa;van Driem, George;Dryomov, Stanislav;Dugoujon, Jean-Michel;Fedorova, Sardana A.;Romero, Irene Gallego;Gubina, Marina;Hammer, Michael;Henn, Brenna M.;Hervig, Tor;Hodoglugil, Ugur;Jha, Aashish R.;Karachanak-Yankova, Sena;Khusainova, Rita;Khusnutdinova, Elza;Kittles, Rick;Kivisild, Toomas;Klitz, William;Kucinskas, Vaidutis;Kushniarevich, Alena;Laredj, Leila;Litvinov, Sergey;Loukidis, Theologos;Mahley, Robert W.;Melegh, Bela;Metspalu, Ene;Molina, Julio;Mountain, Joanna;Nakkalajarvi, Klemetti;Nesheva, Desislava;Nyambo, Thomas;Osipova, Ludmila;Parik, Jueri;Platonov, Fedor;Posukh, Olga;Romano, Valentino;Rothhammer, Francisco;Rudan, Igor;Ruizbakiev, Ruslan;Sahakyan, Hovhannes;Sajantila, Antti;Salas, Antonio;Starikovskaya, Elena B.;Tarekegn, Ayele;Toncheva, Draga;Turdikulova, Shahlo;Uktveryte, Ingrida;Utevska, Olga;Vasquez, Rene;Villena, Mercedes;Voevoda, Mikhail;Winkler, Cheryl A.;Yepiskoposyan, Levon;Zalloua, Pierre;Zemunik, Tatijana;Cooper, Alan;Capelli, Cristian;Thomas, Mark G.;Ruiz-Linares, Andres;Tishkoff, Sarah A.;Singh, Lalji;Thangaraj, Kumarasamy;Villems, Richard;Comas, David;Sukernik, Rem;Metspalu, Mait;Meyer, Matthias;Eichler, Evan E.;Burger, Joachim;Slatkin, Montgomery;Paeaebo, Svante;Kelso, Janet;Reich, David;Krause, Johannes
通讯作者：
Krause, Johannes
影响因子：
4.3
作者：
Kelleher J;Etheridge AM;McVean G
通讯作者：
McVean G
DOI：
10.1016/j.cub.2021.07.022
发表时间：
2021-10-11
期刊：
Current biology : CB
影响因子：
--
作者：
Larena M;McKenna J;Sanchez-Quinto F;Bernhardsson C;Ebeo C;Reyes R;Casel O;Huang JY;Hagada KP;Guilay D;Reyes J;Allian FP;Mori V;Azarcon LS;Manera A;Terando C;Jamero L Jr;Sireg G;Manginsay-Tremedal R;Labos MS;Vilar RD;Latiph A;Saway RL;Marte E;Magbanua P;Morales A;Java I;Reveche R;Barrios B;Burton E;Salon JC;Kels MJT;Albano A;Cruz-Angeles RB;Molanida E;Granehäll L;Vicente M;Edlund H;Loo JH;Trejaut J;Ho SYW;Reid L;Lambeck K;Malmström H;Schlebusch C;Endicott P;Jakobsson M
通讯作者：
Jakobsson M
影响因子：
64.8
作者：
Li, Heng;Durbin, Richard
通讯作者：
Durbin, Richard
影响因子：
64.5
作者：
Browning SR;Browning BL;Zhou Y;Tucci S;Akey JM
通讯作者：
Akey JM