A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective.
A comprehensive review of the impact of COVID-19 on human reproductive biology, assisted reproduction care and pregnancy: a Canadian perspective.
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DOI：
10.1186/s13048-020-00737-1
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发表时间：
2020-11-27
影响因子：
4
通讯作者：
Librach C
中科院分区：
文献类型：
--
作者：
Madjunkov M;Dviri M;Librach C
目前，全球正处于COVID-19大流行的第七个月。在全球范围内，新型SARS-CoV-2病毒感染持续上升，死亡人数不断增加。国际和地方公共卫生应对措施几乎同步实施，以尽量减少病毒传播、卫生系统能力超负荷和个人防护设备不足。虽然在大多数情况下症状轻微或不存在，但SARS-CoV-2感染可导致严重的急性呼吸道疾病和多系统衰竭。研究界以高度的透明度和数据共享对这一新疾病作出了反应;目的是更好地了解起源、病理生理学、流行病学和临床表现。这项研究的最终目标是开发用于预防，缓解策略以及潜在治疗的疫苗。本综述的目的是总结目前关于新型SARS CoV-2的知识，包括其病理生理学和流行病学，以及COVID-19对生殖，生育保健，妊娠和新生儿结局的潜在影响。本摘要还从加拿大的角度评估了这一流行病对生殖保健和研究的影响，并讨论了未来的影响。综上所述，报告的孕妇数据有限，这表明COVID-19在妊娠期间的症状和疾病严重程度与非妊娠妇女相似，妊娠结局与母体疾病严重程度密切相关。SARS-CoV-2对配子影响的证据有限。人类生殖协会已发布COVID-19大流行期间的实践指南，包括在生育护理单位实施缓解措施和感染控制方案。在加拿大，在大流行病开始时实施的限制成功地遏制了感染的蔓延，使人们能够根据新的实践准则最终恢复辅助生殖治疗。加拿大专门拨款支持COVID-19研究，包括一项监测研究，以监测COVID-19在怀孕和辅助生殖期间的结果。必须对新证据进行持续评估，以仔细调整辅助生殖技术（ART）和妊娠期间患者管理的建议。
Currently, the world is in the seventh month of the COVID-19 pandemic. Globally, infections with novel SARS-CoV-2 virus are continuously rising with mounting numbers of deaths. International and local public health responses, almost in synchrony, imposed restrictions to minimize spread of the virus, overload of health system capacity, and deficit of personal protective equipment (PPE). Although in most cases the symptoms are mild or absent, SARS-CoV-2 infection can lead to serious acute respiratory disease and multisystem failure. The research community responded to this new disease with a high level of transparency and data sharing; with the aim to better understand the origin, pathophysiology, epidemiology and clinical manifestations. The ultimate goal of this research is to develop vaccines for prevention, mitigation strategies, as well as potential therapeutics. The aim of this review is to summarize current knowledge regarding the novel SARS CoV-2, including its pathophysiology and epidemiology, as well as, what is known about the potential impact of COVID-19 on reproduction, fertility care, pregnancy and neonatal outcome. This summary also evaluates the effects of this pandemic on reproductive care and research, from Canadian perspective, and discusses future implications. In summary, reported data on pregnant women is limited, suggesting that COVID-19 symptoms and severity of the disease during pregnancy are similar to those in non-pregnant women, with pregnancy outcomes closely related to severity of maternal disease. Evidence of SARS-CoV-2 effects on gametes is limited. Human reproduction societies have issued guidelines for practice during COVID-19 pandemic that include implementation of mitigation practices and infection control protocols in fertility care units. In Canada, imposed restrictions at the beginning of the pandemic were successful in containing spread of the infection, allowing for eventual resumption of assisted reproductive treatments under new guidelines for practice. Canada dedicated funds to support COVID-19 research including a surveillance study to monitor outcomes of COVID-19 during pregnancy and assisted reproduction. Continuous evaluation of new evidence must be in place to carefully adjust recommendations on patient management during assisted reproductive technologies (ART) and in pregnancy.
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影响因子：
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作者：
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DOI：
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