Topography-mediated immunomodulation in osseointegration; Ally or Enemy.
Topography-mediated immunomodulation in osseointegration; Ally or Enemy.
复制标题
DOI：
10.1016/j.biomaterials.2022.121903
复制
发表时间：
2022-12
期刊：
影响因子：
14
通讯作者：
中科院分区：
文献类型：
--
作者：
骨免疫学在骨内种植体骨整合过程中得到充分显示。植入物表面的骨形成、维持和再吸收是骨和免疫细胞之间的双向和动态相互通信的结果，其超出了明确的成骨细胞-破骨细胞信号传导。植入物表面形貌告知粘附祖细胞和免疫细胞功能及其相互作用，以调节骨累积过程。将钛表面工程与免疫学原理相结合，利用免疫系统的力量来改善健康和患病微环境中的骨整合。本综述总结了当前关于免疫细胞-钛植入物表面相互作用的信息，并将这些事件置于表面介导的免疫调节和骨再生的背景下。一个机制的方法是针对在骨整合过程中的骨免疫学的核心作用，并探讨如何调节免疫细胞功能的种植体-骨界面，可用于未来的临床治疗控制。种植体周围骨丢失的过程也通过种植体表面的免疫调节来通知。如何利用表面形貌来防止破骨细胞生成在本文中被认为是相对于种植体周围炎症，破骨细胞-表面相互作用，以及表面形貌对免疫和祖细胞功能的上游/下游影响。
Osteoimmunology is at full display during endosseous implant osseointegration. Bone formation, maintenance and resorption at the implant surface is a result of bidirectional and dynamic reciprocal communication between the bone and immune cells that extends beyond the well-defined osteoblast-osteoclast signaling. Implant surface topography informs adherent progenitor and immune cell function and their cross-talk to modulate the process of bone accrual. Integrating titanium surface engineering with the principles of immunology is utilized to harness the power of immune system to improve osseointegration in healthy and diseased microenvironments. This review summarizes current information regarding immune cell–titanium implant surface interactions and places these events in the context of surface-mediated immunomodulation and bone regeneration. A mechanistic approach is directed in demonstrating the central role of osteoimmunology in the process of osseointegration and exploring how regulation of immune cell function at the implant-bone interface may be used in future control of clinical therapies. The process of peri-implant bone loss is also informed by immunomodulation at the implant surface. How surface topography is exploited to prevent osteoclastogenesis is considered herein with respect to peri-implant inflammation, osteoclastic precursor-surface interactions, and the upstream/downstream effects of surface topography on immune and progenitor cell function.
登录
查看更多内容
影响因子：
4.9
作者：
Adamopoulos IE;Chao CC;Geissler R;Laface D;Blumenschein W;Iwakura Y;McClanahan T;Bowman EP
通讯作者：
Bowman EP
影响因子：
14
作者：
Abaricia, Jefferson O.;Shah, Arth H.;Olivares-Navarrete, Rene
通讯作者：
Olivares-Navarrete, Rene
影响因子：
4.1
作者：
Akintoye, Sunday O.;Lam, Thanh;Robey, Pamela G.
通讯作者：
Robey, Pamela G.
影响因子：
4.9
作者：
Barth, Katrin A.;Waterfield, J. Douglas;Brunette, Donald M.
通讯作者：
Brunette, Donald M.
影响因子：
6.2
作者：
Alexander, Kylie A.;Chang, Ming K.;Pettit, Allison R.
通讯作者：
Pettit, Allison R.