Vaccine development for syphilis.

Vaccine development for syphilis.
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梅毒的疫苗开发。

DOI:
10.1080/14760584.2016.1203262
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发表时间:
2017-01
影响因子:
6.2
通讯作者:
Cameron CE
Cameron CE
中科院分区:
医学2区
文献类型:
--
作者:
Lithgow KV;Cameron CE

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梅毒是由梅毒螺旋体亚种梅毒螺旋体引起的,尽管对青霉素治疗仍然敏感,但它仍然是一种全球流行疾病。梅毒疫苗的开发是一种可行的预防方法,将有助于补充以公共卫生为导向的梅毒预防、筛查和治疗举措,以提供双管齐下的方法来阻止疾病在世界各地的传播。本文概述了开发梅毒疫苗的必要性,总结了从以前的梅毒疫苗研究中获得的重要信息,讨论了梅毒疫苗必须针对的感染的关键方面,并介绍了该领域内对通过接种疫苗所需实现的保护相关因素的当前理解。梅毒疫苗的开发应被行业、监管和资助机构视为优先事项,并应得到适当的促进和支持。
Syphilis, caused by the spirochete Treponema pallidum subspecies pallidum, continues to be a globally prevalent disease despite remaining susceptible to penicillin treatment. Syphilis vaccine development is a viable preventative approach that will serve to complement public health-oriented syphilis prevention, screening and treatment initiatives to deliver a two-pronged approach to stemming disease spread worldwide. This article provides an overview of the need for development of a syphilis vaccine, summarizes significant information that has been garnered from prior syphilis vaccine studies, discusses the critical aspects of infection that would have to be targeted by a syphilis vaccine, and presents the current understanding within the field of the correlates of protection needed to be achieved through vaccination. Syphilis vaccine development should be considered a priority by industry, regulatory and funding agencies, and should be appropriately promoted and supported.
DOI: 10.1097/00007435-198010000-00002
发表时间: 1980-01-01
影响因子: 3.1
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