Glycosylation in Cervical Cancer: New Insights and Clinical Implications.
Glycosylation in Cervical Cancer: New Insights and Clinical Implications.
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DOI：
10.3389/fonc.2021.706862
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发表时间：
2021
影响因子：
4.7
通讯作者：
Mao F
中科院分区：
文献类型：
--
作者：
Xu Z;Zhang Y;Ocansey DKW;Wang B;Mao F
宫颈癌已成为最常见的女性恶性肿瘤，在许多经济发展中的国家是一个普遍的健康挑战。各种人乳头瘤病毒（HPV）类型已成为广泛宫颈癌的最关键可识别原因之一。传统的宫颈细胞学检查有局限性，根据宫颈细胞学的变化敏感性。糖生物学在各种妇科和生殖领域的相关探索中一直是基础，并有助于我们对宫颈癌的理解。它与N-连接聚糖的表达改变以及末端聚糖结构的异常表达有关。监测可用于测定血清和组织糖基化的分析方法，以及细胞糖基化改变中涉及的潜在潜在分子机制。此外，细胞糖基化影响宫颈癌生物学的各个方面，从细胞表面表达，细胞-细胞粘附，癌症信号传导，癌症诊断和管理。总的来说，聚糖谱的发现使得进行血清糖蛋白组学分析在技术上是可重复的和负担得起的，并且建立在探索大多数宫颈癌患者中糖基化标记物的扩展种类的先前工作的基础上。
Cervical cancer has become the most frequent female malignancy and presents as a general health challenge in many countries undergoing economic development. Various human papillomaviruses (HPV) types have appeared as one of the most critically identifiable causes of widespread cervical cancers. Conventional cervical cytological inspection has limitations of variable sensitivity according to cervical cytology. Glycobiology has been fundamental in related exploration in various gynecologic and reproductive fields and has contributed to our understanding of cervical cancer. It is associated with altered expression of N-linked glycan as well as abnormal expression of terminal glycan structures. The analytical approaches available to determine serum and tissue glycosylation, as well as potential underlying molecular mechanisms involved in the cellular glycosylation alterations, are monitored. Moreover, cellular glycosylation influences various aspects of cervical cancer biology, ranging from cell surface expressions, cell-cell adhesion, cancer signaling, cancer diagnosis, and management. In general, discoveries in glycan profiling make it technically reproducible and affordable to perform serum glycoproteomic analyses and build on previous work exploring an expanded variety of glycosylation markers in the majority of cervical cancer patients.
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影响因子：
48
作者：
Chen, Songming;LaRoche, Tom;Haab, Brian B.
通讯作者：
Haab, Brian B.
影响因子：
3.7
作者：
Aco-Tlachi M;Carreño-López R;Martínez-Morales PL;Maycotte P;Aguilar-Lemarroy A;Jave-Suárez LF;Santos-López G;Reyes-Leyva J;Vallejo-Ruiz V
通讯作者：
Vallejo-Ruiz V
影响因子：
34.3
作者：
Arbyn, Marc;Weiderpass, Elisabete;Bray, Freddie
通讯作者：
Bray, Freddie
影响因子：
5.9
作者：
Nomura, Shogo;Egawa, Yasuko;Urano, Sayaka;Tahara, Tsuyoshi;Watanabe, Yasuyoshi;Tanaka, Katsunori
通讯作者：
Tanaka, Katsunori
影响因子：
3.4
作者：
Cisneros-Ramírez D;Martínez-Laguna Y;Martínez-Morales P;Aguilar-Lemarroy A;Jave-Suárez LF;Santos-López G;Reyes-Leyva J;Vallejo-Ruiz V
通讯作者：
Vallejo-Ruiz V