Local field potential recordings in a non-human primate model of Parkinsons disease using the Activa PC + S neurostimulator.
Local field potential recordings in a non-human primate model of Parkinsons disease using the Activa PC + S neurostimulator.
复制标题
DOI：
10.1088/1741-2560/12/6/066012
复制
发表时间：
2015-12
影响因子：
4
通讯作者：
Johnson MD
中科院分区：
文献类型：
--
作者：
Connolly AT;Muralidharan A;Hendrix C;Johnson L;Gupta R;Stanslaski S;Denison T;Baker KB;Vitek JL;Johnson MD
使用美敦力Activa®PC+S系统，研究被动关节操作、伸展行为和脑深部刺激(DBS)对丘脑底核(STN)和苍白球(GP)局部场电位(LFP)活动的调节。五个非人类灵长类动物被单边植入一条或多条DBS导线。LFP是在静息状态和运动任务中的蒙太奇录音中收集的，这些运动任务有助于帕金森氏症运动体征的表达。这些记录是在一名受试者的幼稚状态下，两名受试者的帕金森状态下，以及两名受试者的幼稚和帕金森病状态下进行的。在特定受试者的特定记录位置和帕金森状态下，静息时测量的LFP随着时间的推移是一致的；然而，受试者之间、记录位置之间和记录位置内以及帕金森病状态之间的LFP是高度不同的。在所有记录的核团中，天真和帕金森状态的LFP在β波段(10-30赫兹)都有一个光谱峰值。此外，受试者肢体的被动和主动运动对记录的LFP的光谱内容进行了调制。在线索到达任务期间记录的LFP在STN和GP中显示与任务相关的β去同步化。Activa®PC+S的双向功能还允许在传送DBS的同时录制LFP。STN DBS对帕金森强直的治疗作用持续时间长于刺激30~60岁的S，但与β频段功率无相关性。这项研究强调(1)受试者自发的LFP的变异性和(2)使用Activa®PC+S系统在行为任务中记录神经数据的价值，从而使人们能够评估受试者的症状。
Using the Medtronic Activa® PC + S system, this study investigated how passive joint manipulation, reaching behavior, and deep brain stimulation (DBS) modulate local field potential (LFP) activity in the subthalamic nucleus (STN) and globus pallidus (GP). Five non-human primates were implanted unilaterally with one or more DBS leads. LFPs were collected in montage recordings during resting state conditions and during motor tasks that facilitate the expression of parkinsonian motor signs. These recordings were made in the naïve state in one subject, in the parkinsonian state in two subjects, and in both naïve and parkinsonian states in two subjects. LFPs measured at rest were consistent over time for a given recording location and parkinsonian state in a given subject; however, LFPs were highly variable between subjects, between and within recording locations, and across parkinsonian states. LFPs in both naïve and parkinsonian states across all recorded nuclei contained a spectral peak in the beta band (10–30 Hz). Moreover, the spectral content of recorded LFPs was modulated by passive and active movement of the subjects’ limbs. LFPs recorded during a cued-reaching task displayed task-related beta desynchronization in STN and GP. The bidirectional capabilities of the Activa® PC + S also allowed for recording LFPs while delivering DBS. The therapeutic effect of STN DBS on parkinsonian rigidity outlasted stimulation for 30–60 s, but there was no correlation with beta band power. This study emphasizes (1) the variability in spontaneous LFPs amongst subjects and (2) the value of using the Activa® PC + S system to record neural data in the context of behavioral tasks that allow one to evaluate a subject’s symptomatology.
登录
查看更多内容
影响因子：
5.3
作者：
de Solages, Camille;Hill, Bruce C.;Bronte-Stewart, Helen
通讯作者：
Bronte-Stewart, Helen
影响因子：
5.6
作者：
Fisher, Robert;Salanova, Vicenta;Graves, Nina
通讯作者：
Graves, Nina
影响因子：
4.8
作者：
Burchiel, KJ;Anderson, VC;Hammerstad, JP
通讯作者：
Hammerstad, JP
影响因子：
9.2
作者：
Brittain, John-Stuart;Probert-Smith, Penny;Aziz, Tipu Z.;Brown, Peter
通讯作者：
Brown, Peter
影响因子：
7.7
作者：
Bour, L. J.;Lourens, M. A. J.;Contarino, M. F.
通讯作者：
Contarino, M. F.