The elusive brain perivascular fibroblast: a potential role in vascular stability and homeostasis.
The elusive brain perivascular fibroblast: a potential role in vascular stability and homeostasis.
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DOI：
10.3389/fcvm.2023.1283434
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发表时间：
2023
影响因子：
3.6
通讯作者：
Bonney, Stephanie K.
中科院分区：
文献类型：
--
作者：
Sosa, Maria J.;Shih, Andy Y.;Bonney, Stephanie K.
关键词：
在脑中，血管周围成纤维细胞（PVF）存在于小动脉和大静脉的血管周围空间（PVS）内，但其生理和病理生理作用在很大程度上仍然未知。PVF表达许多细胞外基质蛋白，这些蛋白存在于大直径血管周围的基底膜和PVS中。PVF夹在壁细胞层和星形胶质细胞端足之间，在那里它们准备与壁细胞、血管周围巨噬细胞和星形胶质细胞相互作用。我们在缺血性损伤中更充分研究的PVF促纤维化反应与痴呆和神经退行性疾病中描述的血管壁增厚和PVS扩大之间建立了联系。我们推测PVF可能负责脑血管系统的稳定性和稳态，也可能有助于疾病期间PVS内的变化。
In the brain, perivascular fibroblasts (PVFs) reside within the perivascular spaces (PVSs) of arterioles and large venules, however their physiological and pathophysiological roles remain largely unknown. PVFs express numerous extracellular matrix proteins that are found in the basement membrane and PVS surrounding large diameter vessels. PVFs are sandwiched between the mural cell layer and astrocytic endfeet, where they are poised to interact with mural cells, perivascular macrophages, and astrocytes. We draw connections between the more well-studied PVF pro-fibrotic response in ischemic injury and the less understood thickening of the vascular wall and enlargement of the PVS described in dementia and neurodegenerative diseases. We postulate that PVFs may be responsible for stability and homeostasis of the brain vasculature, and may also contribute to changes within the PVS during disease.
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DOI：
10.1007/s00109-017-1573-x
发表时间：
2017-11
期刊：
Journal of molecular medicine (Berlin, Germany)
影响因子：
--
作者：
Faraco G;Park L;Anrather J;Iadecola C
通讯作者：
Iadecola C
影响因子：
64.5
作者：
Dias DO;Kim H;Holl D;Werne Solnestam B;Lundeberg J;Carlén M;Göritz C;Frisén J
通讯作者：
Frisén J
影响因子：
64.8
作者：
Drieu, Antoine;Du, Siling;Storck, Steffen E.;Rustenhoven, Justin;Papadopoulos, Zachary;Dykstra, Taitea;Zhong, Fenghe;Kim, Kyungdeok;Blackburn, Susan;Mamuladze, Tornike;Harari, Oscar;Karch, Celeste M.;Bateman, Randall J.;Perrin, Richard;Farlow, Martin;Chhatwal, Jasmeer;Hu, Song;Randolph, Gwendalyn J.;Smirnov, Igor;Kipnis, Jonathan
通讯作者：
Kipnis, Jonathan
影响因子：
5.5
作者：
通讯作者：
--
影响因子：
6.3
作者：
Bonney, Stephanie K.;Sullivan, Liam T.;Cherry, Timothy J.;Daneman, Richard;Shih, Andy Y.
通讯作者：
Shih, Andy Y.