Gross tumor volume delineation in primary prostate cancer on (18)F-PSMA-1007 PET/MRI and (68)Ga-PSMA-11 PET/MRI.
Gross tumor volume delineation in primary prostate cancer on (18)F-PSMA-1007 PET/MRI and (68)Ga-PSMA-11 PET/MRI.
复制标题
DOI：
10.1186/s40644-022-00475-1
复制
发表时间：
2022-07-22
期刊：
影响因子：
--
通讯作者：
Xiang ZL
中科院分区：
文献类型：
--
作者：
Zhang YN;Lu ZG;Wang SD;Lu X;Zhu LL;Yang X;Fu LP;Zhao J;Wang HF;Xiang ZL
我们的目的是评估18F-PSMA-1007和68Ga-PSMA-11 PET/MRI在前列腺癌（PCa）放疗的总肿瘤体积（GTV）描绘中的临床价值。69例患者回顾性入选（57例为18F亚组，12例为68Ga亚组）。三位医生分别采用目测法和阈值法分别划定GTV和肿瘤长度，阈值分别为SUVmax的30%、40%、50%和60%。评估gtv的体积相关性和差异。采用骰子相似系数（DSC）估计gtv之间的空间重叠。对51例行根治性前列腺切除术的患者，测量最大面积的肿瘤长度（Lpath），并与基于图像（LMRI、LPET/MRI、LPET、LPET30%、LPET40%、LPET50%、LPET60%）得到的最长肿瘤长度进行比较，确定最佳划定方法。在18F亚组中，(1)GTV-PET/MRI与参考GTV-MRI差异显著（p < 0.001）。两者之间的DSC为bb0 0.7。(2) GTV-MRI是DSC的影响因素（R2 = 0.462, p < 0.05）。68Ga亚组(1)GTV-PET/MRI与对照GTV-MRI差异有统计学意义（p < 0.05）。两者之间的DSC为bb0 0.7。(2) GTV-MRI与DSC有显著相关（r = 0.580, p < 0.05）。在两个亚组中，PET/MRI测量的最长肿瘤长度与组织病理学分析的结果吻合良好。在前列腺癌放疗中，在PSMA PET/MRI上视觉描绘GTV是可行的，我们强调PET/MRI融合图像在GTV描绘中的应用。GTV-MRI与GTV-PET/MRI重叠程度最高，且随体积增大而增大。
We aimed to assess the clinical value of 18F-PSMA-1007 and 68Ga-PSMA-11 PET/MRI in the gross tumor volume (GTV) delineation of radiotherapy for prostate cancer (PCa). Sixty-nine patients were retrospectively enrolled (57 in the 18F subgroup and 12 in the 68Ga subgroup). Three physicians delineated the GTV and tumor length by the visual method and threshold method with thresholds of 30%, 40%, 50%, and 60% SUVmax. The volume correlation and differences in GTVs were assessed. The dice similarity coefficient (DSC) was applied to estimate the spatial overlap between GTVs. For 51 patients undergoing radical prostatectomy, the tumor length (Lpath) of the maximum area was measured, and compared with the longest tumor length obtained based on the images (LMRI, LPET/MRI, LPET, LPET30%, LPET40%, LPET50%, LPET60%) to determine the best delineation method. In the 18F subgroup, (1) GTV-PET/MRI (p < 0.001) was significantly different from the reference GTV-MRI. DSC between them was > 0.7. (2) GTV-MRI (R2 = 0.462, p < 0.05) was the influencing factor of DSC. In the 68Ga subgroup, (1) GTV-PET/MRI (p < 0.05) was significantly different from the reference GTV-MRI. DSC between them was > 0.7. (2) There was a significant correlation between GTV-MRI (r = 0.580, p < 0.05) and DSC. The longest tumor length measured by PET/MRI was in good agreement with that measured by histopathological analysis in both subgroups. It is feasible to visually delineate GTV on PSMA PET/MRI in PCa radiotherapy, and we emphasize the utility of PET/MRI fusion images in GTV delineation. In addition, the overlap degree was the highest between GTV-MRI and GTV-PET/MRI, and it increased with increasing volume.
登录
查看更多内容
影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
1.5
作者：
Ma, Jie-Tao;Han, Cheng-Bo;Guo, Qi-Yong
通讯作者：
Guo, Qi-Yong
DOI：
10.1007/s00259-015-3078-6
发表时间：
2015-07-01
影响因子：
9.1
作者：
Ceci, Francesco;Uprimny, Christian;Virgolini, Irene J.
通讯作者：
Virgolini, Irene J.
DOI：
10.1016/j.ijrobp.2012.01.051
发表时间：
2012-08-01
影响因子：
7
作者：
Viani, Gustavo Arruda;Bernardes da Silva, Lucas Godoi;Stefano, Eduardo Jose
通讯作者：
Stefano, Eduardo Jose
影响因子：
5.7
作者：
Bettermann, Alisa S.;Zamboglou, Constantinos;Grosu, Anca L.
通讯作者：
Grosu, Anca L.