Effects of Early Life Stress on Bone Homeostasis in Mice and Humans.
Effects of Early Life Stress on Bone Homeostasis in Mice and Humans.
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DOI：
10.3390/ijms21186634
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发表时间：
2020-09-10
影响因子：
5.6
通讯作者：
Wippert PM
中科院分区：
文献类型：
--
作者：
Wuertz-Kozak K;Roszkowski M;Cambria E;Block A;Kuhn GA;Abele T;Hitzl W;Drießlein D;Müller R;Rapp MA;Mansuy IM;Peters EMJ;Wippert PM
骨病理是常见的压力个人。缺乏对生活压力、抑郁和骨稳态紊乱之间联系机制的全面研究。在这项转化研究中，通过分析骨矿物质密度（BMD）（DXA）和血清代谢变化（骨钙素、PINP、CTX-I），检查了暴露于早期生活应激（MSUS）的小鼠的骨微结构（μCT）、代谢（qPCR/ELISA）和神经元应激介质表达（qPCR），并与伴或不伴早期生活应激的抑郁症患者样本进行了比较。MSUS小鼠显示NGF、NPYR 1、VIPR 1和TACR 1表达显著降低，骨中神经支配密度较高，血清CTX-1水平升高，表明有利于分解代谢骨转换的环境。与对照小鼠相比，MSUS小鼠的体重显著降低，这对骨微结构造成轻微影响。有童年被忽视经历的抑郁症患者也表现出分解代谢模式。在儿童期有虐待和压力性生活事件的抑郁症患者中观察到BMD显著降低。因此，未来的研究对预防和治疗策略的精神和骨骼疾病应考虑早期生活压力作为一个危险因素的骨骼病变。
Bone pathology is frequent in stressed individuals. A comprehensive examination of mechanisms linking life stress, depression and disturbed bone homeostasis is missing. In this translational study, mice exposed to early life stress (MSUS) were examined for bone microarchitecture (μCT), metabolism (qPCR/ELISA), and neuronal stress mediator expression (qPCR) and compared with a sample of depressive patients with or without early life stress by analyzing bone mineral density (BMD) (DXA) and metabolic changes in serum (osteocalcin, PINP, CTX-I). MSUS mice showed a significant decrease in NGF, NPYR1, VIPR1 and TACR1 expression, higher innervation density in bone, and increased serum levels of CTX-I, suggesting a milieu in favor of catabolic bone turnover. MSUS mice had a significantly lower body weight compared to control mice, and this caused minor effects on bone microarchitecture. Depressive patients with experiences of childhood neglect also showed a catabolic pattern. A significant reduction in BMD was observed in depressive patients with childhood abuse and stressful life events during childhood. Therefore, future studies on prevention and treatment strategies for both mental and bone disease should consider early life stress as a risk factor for bone pathologies.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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通讯作者：
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作者：
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通讯作者：
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