Chemokines, lymphocytes, and HIV.
Chemokines, lymphocytes, and HIV.
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趋化因子、淋巴细胞和 HIV。
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
J. Farber
中科院分区：
文献类型：
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作者：
J. Farber
趋化因子是30多种人类细胞因子家族的成员，其最佳描述的活性是作为白细胞的趋化因子，并且被认为在白细胞募集和运输中是重要的。虽然许多趋化因子可以作用于淋巴细胞，但对趋化因子及其受体在淋巴细胞生物学中的作用知之甚少。最近发现趋化因子可以抑制HIV-1的感染，并且趋化因子受体沿着CD 4作为HIV-1进入的专性共受体，这使得研究趋化因子和淋巴细胞之间的关系变得紧迫。我的实验室已经鉴定了Mig和Crg-2/IP-10，它们是由IFN-γ诱导的趋化因子，并且特异性靶向淋巴细胞，特别是活化的T细胞。我们已经证明，这些趋化因子的基因在实验感染原生动物和病毒病原体的小鼠中广泛表达，但mig和crg-2的表达模式不同，表明在体内的非冗余作用。我们从活化的淋巴细胞中鉴定新趋化因子受体的相关研究导致了STRL 22和STRL 33的克隆。我们和其他人已经表明，STRL 22是CC趋化因子MIP-3 α的受体，STRL 22已被重新命名为CCR 6。虽然STRL 33仍然是孤儿受体，但我们已经表明它可以作为HIV-1包膜糖蛋白的共受体发挥作用，并且它对比迄今为止描述的主要共受体更广泛的HIV-1包膜糖蛋白具有活性。如果建立阻断其他特异性共受体的疗法，STRL 33与各种包膜糖蛋白一起发挥作用的能力可能变得特别重要。我们推测，调查趋化因子及其受体在淋巴细胞生物学中的作用，将提供重要的信息，了解艾滋病的发病机制和操纵免疫和炎症反应的临床效益。
Chemokines are members of a family of more than 30 human cytokines whose best-described activities are as chemotactic factors for leukocytes and that are presumed to be important in leukocyte recruitment and trafficking. While many chemokines can act on lymphocytes, the roles of chemokines and their receptors in lymphocyte biology are poorly understood. The recent discoveries that chemokines can suppress infection by HIV-1 and that chemokine receptors serve, along with CD4, as obligate co-receptors for HIV-1 entry have lent urgency to studies on the relationships between chemokines and lymphocytes. My laboratory has characterized Mig and Crg-2/IP-10, chemokines that are induced by IFN-gamma and that specifically target lymphocytes, particularly activated T cells. We have demonstrated that the genes for these chemokines are widely expressed during experimental infections in mice with protozoan and viral pathogens, but that the patterns of mig and crg-2 expression differed, suggesting non-redundant roles in vivo. Our related studies to identify new chemokine receptors from activated lymphocytes resulted in the cloning of STRL22 and STRL33. We and others have shown that STRL22 is a receptor for the CC chemokine MIP-3 alpha, and STRL22 has been renamed CCR6. Although STRL33 remains an orphan receptor, we have shown that it can function as a co-receptor for HIV-1 envelope glycoproteins, and that it is active with a broader range of HIV-1 envelope glycoproteins than the major co-receptors described to date. The ability of STRL33 to function with a wide variety of envelope glycoproteins may become particularly important if therapies are instituted to block other specific co-receptors. We presume that investigations into the roles of chemokines and their receptors in lymphocyte biology will provide information important for understanding the pathogenesis of AIDS and for manipulating immune and inflammatory responses for clinical benefit.
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DOI：
10.1073/pnas.87.14.5238
发表时间：
1990-07-01
影响因子：
11.1
作者：
FARBER, JM
通讯作者：
FARBER, JM
CRG-2的鉴定。
DOI：
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发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Vanguri,P;Farber,JM
通讯作者：
Farber,JM
影响因子：
56.9
作者：
KOCH, AE;POLVERINI, PJ;STRIETER, RM
通讯作者：
STRIETER, RM
DOI：
10.1084/jem.184.3.1101
发表时间：
1996-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bleul CC;Fuhlbrigge RC;Casasnovas JM;Aiuti A;Springer TA
通讯作者：
Springer TA