Exploiting dendrimer multivalency to combat emerging and re-emerging infectious diseases.
Exploiting dendrimer multivalency to combat emerging and re-emerging infectious diseases.
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DOI：
10.1021/mp2005033
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发表时间：
2012-03-05
影响因子：
4.9
通讯作者：
Grinstaff MW
中科院分区：
文献类型：
--
作者：
Mintzer MA;Dane EL;O'Toole GA;Grinstaff MW
对现有抗生素具有耐药性的细菌菌株的出现和重新出现表明临床需要具有广谱抗菌活性的新药物。此外，抗细菌涂层对医疗设备很重要，因为植入设备的寿命、可靠性和性能会受到细菌粘附和感染的阻碍。树状大分子是一类特殊的单分散大分子，最近显示出作为抗菌剂和抗菌表面涂层的潜力。这篇综述讨论了目前使用的抗菌剂的局限性，并描述了各种类型的树状大分子，包括糖状树状大分子、阳离子状树状大分子、阴离子状树状大分子和肽状树状大分子，如何有潜力改善或取代某些抗生素。此外，将提到这一研究领域中尚未探索的领域，以提供更多关于使用树状大分子作为抗菌剂的研究机会。
The emergence and re-emergence of bacterial strains that are resistant to current antibiotics reveals the clinical need for new agents that possess broad-spectrum antibacterial activity. Furthermore, bacteriophobic coatings that repel bacteria are important for medical devices, as the lifetime, reliability, and performance of implant devices are hindered by bacterial adhesion and infection. Dendrimers, a specific class of monodisperse macromolecules, have recently shown potential to function as both antibacterial agents as well as antimicrobial surface coatings. This review discusses the limitations with currently used antibacterial agents and describes how various classes of dendrimers, including glycodendrimers, cationic dendrimers, anionic dendrimers, and peptide dendrimers, have the potential to improve upon or replace certain antibiotics. Furthermore, the unexplored areas in this field of research will be mentioned to present opportunities for additional studies regarding the use of dendrimers as antimicrobial agents.
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