Cord Blood Biomarkers of Placental Maternal Vascular Underperfusion Predict Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension.
Cord Blood Biomarkers of Placental Maternal Vascular Underperfusion Predict Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension.
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DOI：
10.1016/j.jpeds.2017.01.015
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发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Ernst LM
中科院分区：
文献类型：
--
作者：
Mestan KK;Gotteiner N;Porta N;Grobman W;Su EJ;Ernst LM
目的：评估脐带血生物标志物与胎盘母体血管灌注量不足(MVU)是否预测支气管肺发育不良相关的肺动脉高压(BPD-PH)。参加纵向队列研究的早产儿随机抽取4个胎龄段(n=190，23-36周)。采用多重免疫分析方法对脐带血中的15种血管生成因子进行了检测。根据胎盘组织学MVU，考虑急性/慢性炎症和胎儿血管病理，采用多元线性回归方法比较生物标志物水平。与MVU相关的生物标志物在极低胎龄婴儿(胎龄≤28周；n=48)中进一步评估，并通过另外39名婴儿的酶联免疫分析来确定与BPD(使用美国国立卫生研究院研讨会标准定义)和PH(由36周时的超声心动图确定)的相关性。脐血胎盘生长因子(PIGF)、粒细胞集落刺激因子(G-CSF)、血管内皮生长因子-A随MVU升高而降低(P<0.003)，随BPD-PH升高而降低(P<0.05)。这一发现在另外39名极低胎龄儿中得到了PIGF和G-CSF的验证。在联合组(n=87)中，患有BPD-PH(n=21)的婴儿的PIGF水平低于无BPD-PH的对照组(中位数分别为3pg/mL[IQR2-7]和中位数15pg/mL[IQR6-30]；P<；.001)。BPD-PH组G-CSF的降低与BPD-PH组相似(中位数分别为55pg/mL[IQR 38~85]和中位数243 pg/mL[IQR 48~1593]；P=.001)。受试者曲线分析显示，PIGF和G-CSF降低可预测BPD-PH(曲线下面积分别为0.83和0.76)。随着胎盘MVU的降低，脐血血管生成因子可作为预测BPD-PH的指标。
To assess whether cord blood biomarkers associated with placental maternal vascular underperfusion (MVU) are predictive of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH). Premature infants enrolled in a longitudinal cohort study were randomly sampled from 4 gestational age strata (n = 190, range 23–36 weeks). Fifteen factors from a human angiogenesis panel were measured in cord blood using multiplex immunoassay. Multivariate linear regression was used to compare biomarker levels according to placental histologic MVU, taking into account acute/chronic inflammation and fetal vascular pathology. Biomarkers associated with MVU were further evaluated in the subgroup of extremely low gestational age infants (gestational age ≤ 28 weeks; n = 48), and measured by enzyme-linked immunoassay in an additional 39 infants to determine associations with BPD (defined using the National Institutes of Health workshop criteria) and PH (identified by echocardiogram at 36 weeks of gestation). Cord blood placental growth factor (PIGF), granulocyte-colony stimulating factor (G-CSF), and vascular endothelial growth factor-A were decreased with MVU (P < .003), and decreased with BPD-PH (P < .05). The findings were validated for PIGF and G-CSF in 39 additional extremely low gestational age infants. In the combined group (n = 87), PIGF was decreased in infants with BPD-PH (n = 21) versus controls without PH (median 3 pg/mL [IQR 2–7] vs median 15 pg/mL [IQR 6–30], respectively; P < .001). G-CSF was similarly decreased with BPD-PH (median, 55 pg/mL [IQR 38–85] vs median 243 pg/mL [IQR 48–1593], respectively; P = .001). Receiver operator curve analysis revealed that decreased PIGF and G-CSF were predictive of BPD-PH (area under the curve 0.83 and 0.76, respectively). Cord blood angiogenic factors that are decreased with placental MVU may serve as predictors of BPD-PH.
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胎儿生长限制和支气管肺发育不良的早产儿的肺部高血压。
影响因子：
2.9
作者：
Check, J.;Gotteiner, N.;Liu, X.;Su, E.;Porta, N.;Steinhorn, R.;Mestan, K. K.
通讯作者：
Mestan, K. K.
影响因子：
3.8
作者：
Mestan, K. K.;Check, J.;Ernst, L. M.
通讯作者：
Ernst, L. M.
影响因子：
3.2
作者：
Furuya M;Kurasawa K;Nagahama K;Kawachi K;Nozawa A;Takahashi T;Aoki I
通讯作者：
Aoki I
影响因子：
4.6
作者：
Malamitsi-Puchner A;Boutsikou T;Economou E;Sarandakou A;Makrakis E;Hassiakos D;Creatsas G
通讯作者：
Creatsas G
DOI：
10.1080/15513819609168713
发表时间：
1996-11-01
期刊：
PEDIATRIC PATHOLOGY & LABORATORY MEDICINE
影响因子：
--
作者：
Pinar, H;Sung, CJ;Singer, DB
通讯作者：
Singer, DB