Roles of NUCKS1 in Diseases: Susceptibility, Potential Biomarker, and Regulatory Mechanisms.
Roles of NUCKS1 in Diseases: Susceptibility, Potential Biomarker, and Regulatory Mechanisms.
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NUCKS1 在疾病中的作用：易感性、潜在生物标志物和调节机制
DOI：
10.1155/2018/7969068
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发表时间：
2018
影响因子：
--
通讯作者：
Cui L
中科院分区：
文献类型：
--
作者：
Huang P;Cai Y;Zhao B;Cui L
核酪蛋白激酶和细胞周期蛋白依赖性激酶底物1 （NUCKS1）是一种27 kD染色体高度保守的脊椎动物特异性蛋白。NUCKS1基因编码一种核蛋白，其保守区域包含几个酪蛋白激酶II （CK2）和细胞周期蛋白依赖性激酶（Cdk）的磷酸化位点，以及一个基本的DNA结合域。NUCKS1类似于高迁移群（HMG）家族，其主导染色质重塑并调节基因转录。同时，NUCKS1是RAD51相关蛋白1 （RAD51AP1）的一个同源重组（homologous recombination， HR）和基因组稳定性的重要平行体，也是胰岛素信号成分的转录调节因子。NUCKS1在DNA损伤反应和代谢中发挥重要作用，参与炎症免疫反应，并与microRNA相关。尽管关于NUCKS1的功能信息还不够，但有证据表明，NUCKS1可以作为几种癌症的生物标志物。本文综述了NUCKS1在疾病中的易感性、表达水平、调控机制以及可能的疾病参考功能等方面的最新研究进展。
Nuclear casein kinase and cyclin‐dependent kinase substrate 1 (NUCKS1) is a 27 kD chromosomal, highly conserved, and vertebrate‐specific protein. NUCKS1 gene encodes a nuclear protein and the conserved regions of NUCKS1 contain several consensus phosphorylation sites for casein kinase II (CK2) and cyclin‐dependent kinases (Cdk) and a basic DNA‐binding domain. NUCKS1 is similar to the high mobility group (HMG) family which dominates chromatin remodeling and regulates gene transcription. Meanwhile, NUCKS1 is a RAD51 associated protein 1 (RAD51AP1) paralog that is significant for homologous recombination (HR) and genome stability and also a transcriptional regulator of the insulin signaling components. NUCKS1 plays an important role in DNA damage response and metabolism, participates in inflammatory immune response, and correlates with microRNA. Although there is still not enough functional information on NUCKS1, evidences suggest that NUCKS1 can be used as the biomarker of several cancers. This review summarizes the latest research on NUCKS1 about its susceptibility in diseases, expression levels, and regulatory mechanisms as well as the possible functions in reference to diseases.
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