Structural aspects of plasticity in the nervous system of Drosophila.

Structural aspects of plasticity in the nervous system of Drosophila.
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果蝇神经系统中可塑性的结构方面。

DOI:
10.1186/s13064-018-0111-z
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发表时间:
2018-07-01
期刊:
影响因子:
3.6
通讯作者:
Tavosanis G
Tavosanis G
中科院分区:
生物学3区
文献类型:
--
作者:
Sugie A;Marchetti G;Tavosanis G

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神经元在发育过程中动态地伸展和收缩它们的神经突,以形成复杂的形态,并接触它们适当的突触伴侣。它们进行结构重组的能力在成年期间部分保持,当它支持动物适应不断变化的环境或形成持久记忆的能力时。尽管如此,触发结构可塑性的信号和支持它的机制尚未在分子水平上完全理解。在这里,我们专注于果蝇的神经系统,询问在何种程度上活动调节神经元的形态和发育过程中的连接。此外,我们总结的证据表明,果蝇的成年神经系统保留了一些能力,在突触或电路水平的结构可塑性。为了简单起见,我们选择的例子大多来自视觉系统和蘑菇体的研究,这两个区域是苍蝇大脑中被广泛研究的神经解剖学。
Neurons extend and retract dynamically their neurites during development to form complex morphologies and to reach out to their appropriate synaptic partners. Their capacity to undergo structural rearrangements is in part maintained during adult life when it supports the animal’s ability to adapt to a changing environment or to form lasting memories. Nonetheless, the signals triggering structural plasticity and the mechanisms that support it are not yet fully understood at the molecular level. Here, we focus on the nervous system of the fruit fly to ask to which extent activity modulates neuronal morphology and connectivity during development. Further, we summarize the evidence indicating that the adult nervous system of flies retains some capacity for structural plasticity at the synaptic or circuit level. For simplicity, we selected examples mostly derived from studies on the visual system and on the mushroom body, two regions of the fly brain with extensively studied neuroanatomy.
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