The role of spontaneous neurotransmission in synapse and circuit development.
The role of spontaneous neurotransmission in synapse and circuit development.
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DOI：
10.1002/jnr.24154
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发表时间：
2018-03
影响因子：
4.2
通讯作者：
Burrone J
中科院分区：
文献类型：
--
作者：
Andreae LC;Burrone J
过去，突触前末梢自发释放神经递质被认为是诱发性释放的副作用，功能意义不大。随着我们对自发释放过程的理解随着时间的推移而增加，这个概念逐渐改变。在这篇综述中，我们专注于神经元发育过程中这种形式的释放的重要性，一个时间的极端水平的可塑性，包括树突和轴突的生长以及新的突触接触的形成。这一时期还包括从生长的轴突中释放高水平的神经递质，最近的研究发现，自发的递质释放在塑造神经元形态以及调节大脑中新形成的突触接触的性质方面起着重要作用。在这里，我们汇集了不同物种的最新发现，认为神经递质的自发释放是发育过程中大脑布线的重要参与者。
In the past, the spontaneous release of neurotransmitter from presynaptic terminals has been thought of as a side effect of evoked release, with little functional significance. As our understanding of the process of spontaneous release has increased over time, this notion has gradually changed. In this review, we focus on the importance of this form of release during neuronal development, a time of extreme levels of plasticity that includes the growth of dendrites and axons as well as the formation of new synaptic contacts. This period also encompasses high levels of neurotransmitter release from growing axons, and recent studies have found that spontaneous transmitter release plays an important role in shaping neuronal morphology as well as modulating the properties of newly forming synaptic contacts in the brain. Here, we bring together the latest findings across different species to argue that the spontaneous release of neurotransmitter is an important player in the wiring of the brain during development.
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