Relationship of testosterone and osteocalcin levels during growth.
Relationship of testosterone and osteocalcin levels during growth.
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DOI：
10.1002/jbmr.421
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发表时间：
2011-09
影响因子：
6.2
通讯作者：
Khosla, Sundeep
中科院分区：
文献类型：
--
作者：
Kirmani, Salman;Atkinson, Elizabeth J.;Melton, L. Joseph, III;Riggs, B. Lawrence;Amin, Shreyasee;Khosla, Sundeep
最近在小鼠中的研究表明，骨钙素（OCN）调节雄性睾酮（T）的产生，但不调节雌性。我们假设，这种新的骨-睾丸轴可能是最相关的快速骨骼生长，以帮助最大限度地增加骨的大小。因此，我们测量了56名男孩（骨龄4-20岁）的血清T、总OCN和低羧化（UC）OCN以及桡骨骨膜周长。T与OCN相关（骨龄校正r = 0.30，P = 0.024），UC OCN的趋势相似。男孩骨龄11岁时T开始增加，OCN在骨龄14岁时达到峰值。因此，我们将男孩分为3组：4-10岁（n = 16），11-14岁（n = 18）和15-20岁（n = 22）。在骨龄11-14岁的男孩中（而不是其他两组），OCN与T相关（r = 0.57，P = 0.013），UC OCN的趋势相似; T反过来与骨膜周长相关（r = 0.75，P < 0.001）。总的来说，这些发现支持了最近在小鼠中观察到的新的骨-睾丸轴。此外，我们的数据表明，在人类男性中，当T水平在下丘脑-垂体轴的影响下上升并且OCN由于骨骼生长而增加时，该轴可能在快速骨骼生长期间最相关：在此阶段，OCN可能进一步刺激睾丸T产生，这反过来有助于骨骼大小的增加。
Recent studies in mice have demonstrated that osteocalcin (OCN) regulates testosterone (T) production in males, but not in females. We hypothesized that this novel bone-testis axis may be most relevant during rapid skeletal growth to help maximize bone size. Thus, we measured serum T, total and undercarboxylated (UC) OCN, and periosteal circumference at the radius in 56 boys (bone age 4–20 years). T was correlated with OCN (bone age-adjusted r = 0.30, P = 0.024), with a similar trend for UC OCN. T began to increase in the boys at bone age 11 years, and OCN peaked at bone age 14 years. Thus, we divided the boys into 3 groups: 4–10 years (n = 16), 11–14 years (n = 18), and 15–20 years (n = 22). In boys of bone age 11–14 years (but not the other two groups) OCN was correlated with T (r = 0.57, P = 0.013), with a similar trend for UC OCN; T, in turn, was correlated with periosteal circumference (r = 0.75, P < 0.001). Collectively, these findings support the recent observations in mice of a novel bone-testis axis. Moreover, our data suggest that in human males, this axis may be most relevant during rapid skeletal growth, when T levels are rising under the influence of the hypothalamic-pituitary axis and OCN is increasing due to skeletal growth: during this phase, OCN may further stimulate testicular T production which, in turn, contributes to an increase in bone size.
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影响因子：
--
作者：
Hayes, FJ;Crowley, WF
通讯作者：
Crowley, WF
影响因子：
6.2
作者：
Kirmani, Salman;Christen, David;Khosla, Sundeep
通讯作者：
Khosla, Sundeep
影响因子：
4
作者：
Khosla, S.;Amin, S.;Riggs, B. L.
通讯作者：
Riggs, B. L.
影响因子：
5.8
作者：
Gundberg, CM;Nieman, SD;Rosen, H
通讯作者：
Rosen, H
影响因子：
64.5
作者：
Fulzele K;Riddle RC;DiGirolamo DJ;Cao X;Wan C;Chen D;Faugere MC;Aja S;Hussain MA;Brüning JC;Clemens TL
通讯作者：
Clemens TL