The Oxytocin Product Correlates with Total Oxytocin Received during Labor: A Research Methods Study.
The Oxytocin Product Correlates with Total Oxytocin Received during Labor: A Research Methods Study.
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DOI：
10.1055/s-0037-1606119
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发表时间：
2018-01
影响因子：
2
通讯作者：
Deneux-Tharaux C
中科院分区：
文献类型：
--
作者：
Grotegut CA;Lewis LL;Manuck TA;Allen TK;James AH;Seco A;Deneux-Tharaux C
分娩期间获得的催产素总剂量是人类分娩研究中的一个重要变量，但很难计算。我们试图确定催产素总剂量的替代测量方法。对于每个在分娩期间接受催产素的受试者，在分娩期间获得的催产素总剂量被计算为曲线下的面积。然后，使用皮尔逊相关系数，将最大催产素输注速率、催产素输注总时间以及两者的乘积定义为催产素乘积，每一个都与所接受的催产素总剂量相关。杜克大学的402名女性和皮萨戈雷的6907名女性获得了催产素的剂量数据。这两个变量单独或合并为催产素乘积，与催产素总剂量(r>；0.7)显示出高度的相关性，其中催产素乘积显示最高(r>；0.9)。无论是引产还是扩大分娩，无论是阴道分娩还是剖腹产，都是如此。催产素乘积由两个容易获得的变量组成，显示出与分娩中接受的催产素总剂量非常高的相关性，并代表了分娩期间接受的催产素总剂量的简单而准确的替代。催产素产物可用于临床研究，其中催产素剂量是一个重要的变量。
Total dose of oxytocin received during labor is an important variable in studies of human labor but is difficult to calculate. We sought to identify a surrogate measure for total dose of oxytocin received. For each subject receiving oxytocin during labor, the oxytocin total dose received in labor was calculated as the area under the curve. Maximal oxytocin infusion rate, total duration of oxytocin infusion, and the product of both, defined as the oxytocin product, were then each correlated with the total dose of oxytocin received using the Pearson’s correlation coefficient. Oxytocin dosing data were available from 402 women at Duke and 6,907 women from Pithagore6. The two variables alone, or combined as the oxytocin product, demonstrated a high correlation with the oxytocin total dose (r > 0.7), with the oxytocin product demonstrating the highest (r > 0.9). This was true whether labor was induced or augmented and whether delivery was vaginal or cesarean. The oxytocin product, composed of two easily obtained variables, demonstrated a very high correlation with total oxytocin dose received in labor and represents a simple and accurate surrogate for total dose of oxytocin received during labor. The oxytocin product can be used in clinical studies in which oxytocin dose is an important variable.
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影响因子：
4.3
作者：
Kjaergaard, Hanne;Olsen, Jorn;Dykes, Anna-Karin
通讯作者：
Dykes, Anna-Karin
DOI：
10.1016/s0002-9378(84)90355-7
发表时间：
1984-01-01
影响因子：
9.8
作者：
SEITCHIK, J;AMICO, J;CASTILLO, M
通讯作者：
CASTILLO, M
DOI：
10.1111/j.1471-0528.2010.02648.x
发表时间：
2010-09-01
影响因子：
5.8
作者：
Deneux-Tharaux, C.;Dupont, C.;Rudigoz, R.
通讯作者：
Rudigoz, R.
影响因子：
--
作者：
Grotegut, Chad A.;Mao, Lan;Murtha, Amy P.
通讯作者：
Murtha, Amy P.
影响因子：
9.8
作者：
Grotegut, Chad A.;Paglia, Michael J.;James, Andra H.
通讯作者：
James, Andra H.