Fibroblast growth factor-23 and subclinical markers of cardiac dysfunction: The coronary artery risk development in young adults (CARDIA) study.
Fibroblast growth factor-23 and subclinical markers of cardiac dysfunction: The coronary artery risk development in young adults (CARDIA) study.
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DOI：
10.1016/j.ahj.2021.11.009
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发表时间：
2022-03
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
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成纤维细胞生长因子-23（FGF 23）水平升高与左心室质量（LVM）和心力衰竭有关。在无心血管疾病（CVD）或慢性肾脏疾病（CKD）的中年人中，较高的FGF 23是否与较高的LVH患病率和左心室质量纵向变化以及心肌应变相关尚不清楚。我们研究了3113名基线时没有CVD的成年人，他们参加了年轻人冠状动脉风险发展（CARDIA）研究的25年（2010-2011）随访检查。我们研究了25岁C-末端FGF 23浓度与指数化左心室质量（LVMI=左心室质量/身高2.7）、左心室肥厚和心肌应变的相关性，如斑点追踪应变超声心动图所评估的。在2758名（88.6%）返回进行30年检查的参与者中，我们还调查了25年FGF 23与LVMI、应变参数和LVH事件的5年变化的相关性。平均年龄为50.0（±3.6）岁，56.8%为女性，45.7%为黑人，6.4%患有CKD。第25年时LVH患病率为6.0%。LVMI的平均5年变化为5.3（±7.7）g/m。在多变量模型中，与低四分位数相比，最高四分位数的FGF 23与25年时LVH的更大几率相关。[Odds比率95% CI：1.81（1.28，2.58）]，排除CKD受试者后的结果相似。FGF 23与种族（p=0.18）或性别（p=0.80）之间没有相互作用。FGF 23与全局纵向应变之间没有关联。FGF 23与LVMI的5年变化之间无相关性。高FGF 23与5年LVH事件之间无相关性。在没有已知CVD或CKD的中年成人人群中，较高的FGF 23与LVH的可能性较大相关，但与随时间推移的LVM增加无关。需要进一步研究来阐明FGF 23是否是潜在LVH的风险标志物，或者是无CKD的年轻和中年成人人群中随时间推移而增加的左心室质量的机制。
Elevated Fibroblast Growth Factor-23 (FGF23) levels have been associated with greater left ventricular mass (LVM) and heart failure. Whether higher FGF23 is associated with higher LVH prevalence and longitudinal changes in LVM and myocardial strain in middle-aged adults without cardiovascular disease (CVD) or chronic kidney disease (CKD) is unknown. We studied 3113 adults without CVD at baseline participating in the Year 25 (2010–2011) follow-up exam of the Coronary Artery Risk Development in Young Adults (CARDIA) study. We studied the association of Year 25 c-terminal FGF23 concentrations with indexed LVM (LVMI=LVM/height2.7), LVH and myocardial strain as assessed by speckle tracking strain echocardiography. Among the 2758 (88.6%) participants who returned for the Year 30 examination, we also investigated the association of Year 25 FGF23 with 5-Year change in LVMI, strain parameters and incident LVH. The mean age was 50.0 (±3.6) years, 56.8% were female, 45.7% were Black and 6.4% had CKD. There was 6.0% LVH prevalence at Year 25. Mean 5-Year change in LVMI was 5.3 (±7.7) grams/meter. In multivariable models, FGF23 in the highest quartile was associated with greater odds of LVH at Year 25 compared to lower quartiles. [Odds Ratio 95% CI: 1.81 (1.28, 2.58)] with similar findings after exclusion of participants with CKD. There was no interaction between FGF23 and race (p=0.18) or sex (p=0.80). There was no association between FGF23 and global longitudinal strain. There was no association between FGF23 and 5-Year change in LVMI. There was no association between higher FGF23 and 5-year incident LVH. In a middle-aged adult population without known CVD or CKD, higher FGF23 was associated with greater odds of LVH, but not with greater increases in LVM over time. Further study is needed to elucidate whether FGF23 is a risk marker for underlying LVH or a mechanism for increased LVM over time in younger and middle-aged adult populations without CKD.
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DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
DOI：
10.1111/echo.12832
发表时间：
2015-08
期刊：
Echocardiography (Mount Kisco, N.Y.)
影响因子：
--
作者：
Armstrong AC;Ricketts EP;Cox C;Adler P;Arynchyn A;Liu K;Stengel E;Sidney S;Lewis CE;Schreiner PJ;Shikany JM;Keck K;Merlo J;Gidding SS;Lima JA
通讯作者：
Lima JA
影响因子：
6.2
作者：
Lang, Roberto M.;Badano, Luigi P.;Voigt, Jens-Uwe
通讯作者：
Voigt, Jens-Uwe
影响因子：
5.4
作者：
Kishi, Satoru;Reis, Jared P.;Lima, Joao A. C.
通讯作者：
Lima, Joao A. C.
DOI：
10.1097/00008483-198911000-00003
发表时间：
1989-11-01
期刊：
Journal of cardiopulmonary rehabilitation
影响因子：
--
作者：
Jacobs, David R Jr;Hahn, Lorraine P;Sidney, Stephen
通讯作者：
Sidney, Stephen